铍针治疗末梢神经张力性疼痛的机理研究
发布时间：2018-12-29 08:37
【摘要】：1.目的 探索铍针治疗末梢神经张力性疼痛的机理,评价铍针疗法的安全性、有效性,为铍针疗法的临床应用及推广提供实验依据。2.方法2.1造模 用Wistar大鼠80只,随机分为5组,每组16只。A组：不做任何处理；B组：将大鼠双侧隐神经做适当游离,不进行卡压处理；C组：以内径0.5mm的硅胶管卡压大鼠双侧隐神经；D组：以内径0.4mm的硅胶管卡压大鼠双侧隐神经；E组：以内径0.3mm的硅胶管卡压大鼠双侧隐神经。各组术后1个月每组随机抽取8只大鼠进行隐神经大体形态观察和电生理学检测。 2.2铍针治疗 1个月造模成功后,对A组大鼠不做任何处理,对B、C、D、E组每组余下8只大鼠进行铍针治疗,每周一次,治疗三周。治疗结束后,对每组大鼠进行大体形态观察和电生理学检测。 3.结果 经铍针治疗后,B、C、D组的神经传导速度较治疗前均有所好转(P0.05),说明铍针对B、C、D组治疗有效；A组未进行任何处理,前后相差不明显(P0.05)；E组治疗后仍未引出动作电位,说明E组神经损伤严重,铍针治疗无效。铍针治疗后,A、B两组比较,P0.05,差异无统计学意义,说明A、B两组神经传导速度相差不明显；B、C两组比较,P0.05,差异有统计学意义,说明虽然B、C两组神经传导速度较铍针治疗前有所好转,但C组神经传导速度小于B组；C、D两组比较,P0.05,差异有统计学意义,说明虽然C、D两组神经传导速度较铍针治疗前有所好转,但D组神经传导速度小于C组。该实验结果显示铍针治疗皮神经卡压造成的神经损伤有一定效果,但随着卡压硅胶管内径的缩小,压力增加,神经损伤程度加重,铍针的疗效会相应降低,当神经损伤严重,造成不可逆性损伤时,铍针治疗无效。 4.结论 铍针治疗末梢神经张力性疼痛,具有不需要麻醉、创伤小、痛苦小、术中对神经周围组织的损伤少、术后神经周围形成的疤痕小、定位准确、松解较为充分、症状改善明显等特点。是一种安全、简便、疗效肯定、易于推广的新疗法,它的出现为临床常见的疼痛性疾病的治疗开辟了新的思路,适合在基层广泛推广应用。
[Abstract]:1. Objective to explore the mechanism of beryllium acupuncture in the treatment of peripheral nerve tensional pain, to evaluate the safety and efficacy of beryllium needle therapy, and to provide experimental evidence for clinical application and popularization of beryllium needle therapy. Methods 80 Wistar rats were randomly divided into 5 groups, 16 rats in each group. Group A: no treatment, group B: the bilateral saphenous nerve was dissociated properly, and the bilateral saphenous nerve was not compressed. In group C, bilateral saphenous nerve was compressed with silica gel tube with inner diameter of 0.5mm, group D with silica gel tube with inner diameter of 0.4mm, group E with silica gel tube with inner diameter of 0.3mm to compress bilateral saphenous nerve of rats. One month after operation, 8 rats in each group were randomly selected to observe the saphenous nerve gross morphology and electrophysiology. 2.2 the rats in group A were treated with beryllium needle once a week for three weeks, and the remaining 8 rats in group A were treated with beryllium needle once a week. After the treatment, the gross morphology and electrophysiology of each group were observed. 3. Results after treatment with beryllium needle, the nerve conduction velocity in group B was better than that in group B (P0.05), which indicated that beryllium was effective in group B CfU D. Group A did not have any treatment, the difference was not significant (P0.05); E group after treatment still did not elicit action potential, indicating that group E nerve injury is serious, beryllium needle treatment is not effective. After beryllium needle treatment, there was no significant difference in nerve conduction velocity between the two groups (P 0.05), indicating that there was no significant difference in nerve conduction velocity between the two groups. The difference between group B and C was statistically significant (P 0.05), which indicated that although the nerve conduction velocity of group B was better than that of group B before beryllium needle therapy, the nerve conduction velocity of group C was lower than that of group B; The difference between group C and D was statistically significant (P 0.05), which indicated that although the nerve conduction velocity of group C was better than that of group C before beryllium needle therapy, the nerve conduction velocity of group D was lower than that of group C. The experimental results show that beryllium needle has a certain effect on nerve injury caused by cutaneous nerve entrapment. However, with the reduction of internal diameter of compressed silica gel tube, the increase of pressure and the severity of nerve injury, the curative effect of beryllium needle will be reduced accordingly, when the nerve injury is serious, When irreversibility injury is caused, beryllium needle therapy is ineffective. 4. Conclusion beryllium needle has no need of anesthesia, less trauma, less pain, less injury to peripheral nerve tissue, small scar around nerve after operation, accurate orientation and sufficient release. Symptoms improved obviously and so on. It is a safe, simple, effective and easy to popularize new therapy. It opens up a new idea for the treatment of common clinical pain diseases, and is suitable for wide application at the grass-roots level.
【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R245
本文编号：2394592
[Abstract]:1. Objective to explore the mechanism of beryllium acupuncture in the treatment of peripheral nerve tensional pain, to evaluate the safety and efficacy of beryllium needle therapy, and to provide experimental evidence for clinical application and popularization of beryllium needle therapy. Methods 80 Wistar rats were randomly divided into 5 groups, 16 rats in each group. Group A: no treatment, group B: the bilateral saphenous nerve was dissociated properly, and the bilateral saphenous nerve was not compressed. In group C, bilateral saphenous nerve was compressed with silica gel tube with inner diameter of 0.5mm, group D with silica gel tube with inner diameter of 0.4mm, group E with silica gel tube with inner diameter of 0.3mm to compress bilateral saphenous nerve of rats. One month after operation, 8 rats in each group were randomly selected to observe the saphenous nerve gross morphology and electrophysiology. 2.2 the rats in group A were treated with beryllium needle once a week for three weeks, and the remaining 8 rats in group A were treated with beryllium needle once a week. After the treatment, the gross morphology and electrophysiology of each group were observed. 3. Results after treatment with beryllium needle, the nerve conduction velocity in group B was better than that in group B (P0.05), which indicated that beryllium was effective in group B CfU D. Group A did not have any treatment, the difference was not significant (P0.05); E group after treatment still did not elicit action potential, indicating that group E nerve injury is serious, beryllium needle treatment is not effective. After beryllium needle treatment, there was no significant difference in nerve conduction velocity between the two groups (P 0.05), indicating that there was no significant difference in nerve conduction velocity between the two groups. The difference between group B and C was statistically significant (P 0.05), which indicated that although the nerve conduction velocity of group B was better than that of group B before beryllium needle therapy, the nerve conduction velocity of group C was lower than that of group B; The difference between group C and D was statistically significant (P 0.05), which indicated that although the nerve conduction velocity of group C was better than that of group C before beryllium needle therapy, the nerve conduction velocity of group D was lower than that of group C. The experimental results show that beryllium needle has a certain effect on nerve injury caused by cutaneous nerve entrapment. However, with the reduction of internal diameter of compressed silica gel tube, the increase of pressure and the severity of nerve injury, the curative effect of beryllium needle will be reduced accordingly, when the nerve injury is serious, When irreversibility injury is caused, beryllium needle therapy is ineffective. 4. Conclusion beryllium needle has no need of anesthesia, less trauma, less pain, less injury to peripheral nerve tissue, small scar around nerve after operation, accurate orientation and sufficient release. Symptoms improved obviously and so on. It is a safe, simple, effective and easy to popularize new therapy. It opens up a new idea for the treatment of common clinical pain diseases, and is suitable for wide application at the grass-roots level.
【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R245
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