帕瑞昔布对老年肝癌患者右肝部分切除术中肝脏缺血再灌注损伤炎性介质变化的影响

发布时间：2019-01-10 16:49

【摘要】：目的探讨帕瑞昔布对老年肝癌患者右肝部分切除术中肝脏缺血再灌注损伤(HIRI)炎性介质的影响。方法择期行右肝部分切除术老年肝癌患者60例随机均分为对照组(C组)和帕瑞昔布组(P组)各30例。肝门阻断前60 min,P组静脉注射帕瑞昔布40 mg,C组注射生理盐水。于麻醉诱导前(T0)、肝门开放15 min(T1)、再灌注1 h(T2)、6 h(T3)、24 h(T4)5个时相点抽取静脉血检测谷丙转氨酶(ALT)、谷草转氨酶(AST)、肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6和IL-10浓度的变化。结果两组T0时ALT、AST、TNF-α、IL-6和IL-10水平差异无统计学意义(P0.05);与T0比较,两组ALT、AST在T1、T2、T3、T4明显升高(P0.05);P组在再灌注后各时点的ALT、AST水平均明显低于C组(P0.05)。与T0比较,T1、T2、T3、T4时两组TNF-α、IL-6和IL-10水平明显升高(P0.05)。与C组比较,T1、T2、T3、T4时P组TNF-α、IL-6水平明显降低(P0.05),IL-10水平明显升高(P0.05)。结论帕瑞昔布钠对老年肝癌患者右肝部分切除术中HIRI具有一定的保护作用。
[Abstract]:Objective to investigate the effect of paroxib on (HIRI) inflammatory mediators during partial hepatectomy in elderly patients with liver ischemia reperfusion injury. Methods 60 elderly patients with liver cancer undergoing partial right hepatectomy were randomly divided into two groups: control group (group C) and paroxib group (group P). 60 min,P before hepatic portal occlusion, paroxib 40 mg,C was injected intravenously into saline group. Before anesthesia induction (T0), hepatic hilum was opened for 15 min (T1), reperfusion for 1 h (T2), 6 h (T3), 24 h (T4) for the detection of (ALT), (ALT), transaminase (AST),. Changes of tumor necrosis factor (TNF)-伪, interleukin (IL)-6 and IL-10 concentrations. Results there was no significant difference in the levels of ALT,AST,TNF- 伪, IL-6 and IL-10 between the two groups at T0 (P0.05), and ALT,AST was significantly higher in T1T2T3T4 than that in T0 (P0.05). The level of ALT,AST in group P was significantly lower than that in group C at all time points after reperfusion (P0.05). Compared with T0, the levels of TNF- 伪, IL-6 and IL-10 in T1T2T3T4 group were significantly higher than those in T0 group (P0.05). Compared with group C, the levels of TNF- 伪 and IL-6 in group P were significantly lower than those in group C (P0.05) and the level of IL-10 was significantly increased (P0.05). Conclusion paroxib sodium has a protective effect on HIRI during partial resection of right liver in elderly patients with liver cancer.
【作者单位】：吉林大学第一医院麻醉科;吉林大学第四医院肾内科;
【基金】：吉林省自然科学基金(201015121)
【分类号】：R735.7;R614

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