右美托咪定对依托咪酯抑制气管插管反应半数有效血药浓度的影响

发布时间：2019-01-24 21:43

【摘要】：目的:通过改良序贯法测定右美托咪定对依托咪酯血浆靶控输注抑制气管插管反应半数有效血浆浓度(Cp50)的影响。方法:将择期全麻老年患者随机分为两组,全麻诱导时A组预注0.5μg/kg右美托咪定,B组配同容量的生理盐水,静脉恒速输注10 min,静脉靶控输注依托咪酯目标血浆靶浓度按照改良序贯法设定,根据预试验设定A组第1例起始浓度是0.30μg/m L,B组是0.40μg/m L,相邻浓度增加或降低0.1μg/m L,出现6个交叉点时试验结束。结果:实际A组21例、B组18例纳入统计。采用概率单位回归分析法计算,A组依托咪酯抑制气管插管反应的Cp50为0.62μg/m L(95%CI∶0.49~0.76μg/m L);B组Cp50为0.91μg/m L(95%CI∶0.79~1.07μg/m L)。结论:右美托咪定可明显减少依托咪酯血浆靶控输注抑制老年患者气管插管反应的Cp50,联合应用时应注意适当减量。
[Abstract]:Aim: to determine the effect of dexmetomidine on the half effective plasma concentration (Cp50) of etomidate in the inhibition of tracheal intubation by modified sequential method. Methods: elderly patients undergoing elective general anesthesia were randomly divided into two groups: group A was preinjected with dexmetidine 0.5 渭 g/kg and group B was given 10 min, intravenous infusion of normal saline of the same volume during induction of general anesthesia. The target plasma concentration of etomidate was set according to the modified sequential method. The initial concentration of the first case in group A was 0.30 渭 g / m L ~ (-1), and that in group B was 0.40 渭 g / m ~ (L), and the adjacent concentration increased or decreased by 0.1 渭 g / m ~ (L). The test is over when six intersections occur. Results: 21 cases in group A and 18 cases in group B were included in the statistics. Using probabilistic unit regression analysis, the Cp50 of etomidate inhibiting tracheal intubation in group A was 0.62 渭 g / mL (Cp50 = 0.91 渭 g / m L). In 95%CI:0.49~0.76 渭 g / m L); B group). Conclusion: dexmetomidine can significantly reduce the amount of Cp50, combined with etomidate plasma target-controlled infusion to inhibit tracheal intubation in elderly patients.
【作者单位】：南方医科大学南方医院麻醉科;
【基金】：南方医科大学南方医院院长基金(2014B018)
【分类号】：R614

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