帕瑞昔布超前镇痛在全麻大容量肺灌洗术中的应用

发布时间：2019-02-18 14:34

【摘要】：目的探讨帕瑞昔布超前镇痛对气管插管全身麻醉患者麻醉效果的影响。方法将100例尘肺患者随机分为帕瑞昔布组及对照组,每组50例。两组均于气管插管全麻下行大容量单肺灌洗术。帕瑞昔布组于诱导前20 min静脉注射帕瑞昔布40 mg,对照组静脉注射等量生理盐水。比较两组手术时间、术后苏醒时间、苏醒期平均动脉压(MAP)、心率(HR)、动脉血氧饱和度(Sp O2)的变化及苏醒期躁动发生率、术后24 h咽喉痛发生率。结果两组手术时间、苏醒时间差异均无统计学意义。帕瑞昔布组苏醒期MAP、HR均低于对照组(P0.05),帕瑞昔布组苏醒期躁动发生率及术后24 h咽喉痛发生率均低于对照组(P均0.05)。结论帕瑞昔布超前镇痛可抑制全麻患者术后苏醒期躁动,降低术后24 h咽喉痛的发生率。
[Abstract]:Objective to investigate the effect of preemptive analgesia with paroxib on the anesthetic effect of tracheal intubation general anesthesia. Methods 100 patients with pneumoconiosis were randomly divided into two groups: paroxib group and control group. Large volume single lung lavage was performed under tracheal intubation and general anesthesia in both groups. Paroxib group received paroxib 40 mg, intravenously 20 min before induction. The changes of mean arterial pressure (MAP), arterial oxygen saturation (Sp O 2), arterial oxygen saturation (Sp O 2) and arthralgia at 24 h after operation were compared between the two groups. Results there was no significant difference in operation time and recovery time between the two groups. The MAP,HR in the paroxib group was lower than that in the control group (P0.05), and the incidence of restlessness and larynx pain at 24 hours after operation in the paroxib group was lower than that in the control group (P0.05). Conclusion Paroxib preemptive analgesia can inhibit restlessness and reduce the incidence of pharynx and larynx pain 24 hours after operation in patients with general anesthesia.
【作者单位】：三峡大学第一临床医学院;
【基金】：宜昌市科技局基金资助项目(A14-30323)
【分类号】：R614.2

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