丙泊酚在高血压脑出血患者围术期的麻醉效果及脑保护作用

发布时间：2019-04-21 14:55

【摘要】：目的:对丙泊酚在高血压脑出血患者围手术期的麻醉效果与脑保护功能予以探究。方法:选取2012年1月~2015年1月我院接收的高血压脑出血患者80例作为研究对象,全部患者实施开颅血肿清除手术,按就诊单双数顺序法分为实验组与参照组,分别予以丙泊酚、咪达唑仑麻醉。比较两组患者的麻醉效果与脑保护情况。结果:实验组患者T1、T2、T3的心率和收缩压与T0相比,存在明显差异,有统计学意义(P0.05);两组患者T_1、T_2、T_3的CjVO_2、CaO_2、Da-jvO_2指标与T0相比,差异有统计学意义(P0.05);实验组T1、T2、T3的CjVO_2、CaO——2、Da-jvO——2指标与参照组相比,差异有统计学意义(P0.05);两组患者T3的CEO2与T0相比,差异存在统计学意义(P0.05);实验组不良反应发生率(17.5%)低于参照组(37.5%),差异具备统计学意义(P0.05)。结论:对行手术治疗的高血压脑出血患者予以丙泊酚麻醉,效果显著,且可发挥脑保护的作用,值得在临床上推广。
[Abstract]:Objective: to explore the anesthetic effect and brain protective function of propofol in patients with hypertensive intracerebral hemorrhage (EH) during perioperative period. Methods: 80 patients with hypertensive intracerebral hemorrhage received in our hospital from January 2012 to January 2015 were selected as the study subjects. All the patients underwent craniotomy and were divided into experimental group and control group according to single or even order of visit, and propofol was given respectively. Midazolam anesthesia. The effects of anesthesia and brain protection were compared between the two groups. Results: the heart rate (HR) and systolic pressure (SBP) of T _ 1, T _ 2 and T _ 3 in the experimental group were significantly different from those in the T _ 0 group (P0.05). There was a significant difference in CjVO_2,CaO_2,Da-jvO_2 between the two groups (P0.05), compared with the T0 (P < 0.05), and there was a significant difference between the two groups (P < 0.05). The CjVO_2,CaO--2,Da-jvO--2 indexes of T1, T2, T3 in the experimental group were significantly higher than those in the control group (P0.05); the CEO2 of T3 in the two groups was significantly higher than that in the T0 group (P0.05); The incidence of adverse reactions in the experimental group (17.5%) was lower than that in the control group (37.5%), the difference was statistically significant (P0.05). Conclusion: propofol anesthesia is effective and can protect the brain in patients with hypertensive intracerebral hemorrhage treated by operation, and it is worth popularizing in clinic.
【作者单位】：东莞市黄江医院麻醉科;东莞市黄江医院神经外科;
【基金】：广东省东莞市科技计划项目(编号:2014105101125)
【分类号】：R614

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