探讨七氟醚丙泊酚复合麻醉对于老年胃癌患者术后早期认知功能的影响
发布时间：2019-04-30 14:01
【摘要】：目的探讨七氟醚丙泊酚复合麻醉对于老年胃癌患者术后早期认知功能的影响。方法选取2014年2月至2015年4月期间我院收治的老年胃癌患者80例为研究对象,按照随机数字法将其分为实验组和对照组各40例。实验组采用七氟醚丙泊酚复合麻醉,对照组采用瑞芬太尼丙泊酚复合麻醉,比较两组患者的术后清醒时间、拔管时间和术后MMSE评分。结果实验组术后清醒时间为(15.44±3.23)min,明显快于对照组(18.73±3.67)min,差异显著(P0.05),具有统计学意义;实验组拔管时间为(22.68±3.75)min,明显快于对照组(28.65±5.13)min,差异显著(P0.05),具有统计学意义;两组术后MMSE评分均有降低,但实验组术后3h MMSE评分为(19.22±1.88)分,术后6h MMSE评分为(21.62±1.57)分,术后24h MMSE评分为(27.18±1.13)分,术后72h MMSE评分为(24.82±1.77)分,术后96h MMSE评分为(28.92±2.52)分;相较于对照组术后3h MMSE评分为(23.71±2.18)分,术后6h MMSE评分为(25.65±1.13)分,术后24h MMSE评分为(27.57±2.04)分,术后72h为MMSE评分(26.92±1.83)分,术后96h MMSE评分为(27.26±1.93)分,实验组明显降低效果更佳,差异显著(P0.05),具有统计学意义。结论采用七氟醚丙泊酚复合麻醉,具有术后清醒时间快、拔管时间快、术后MMSE评分低的优势,并且七氟醚会影响海马区LTP形成,其具备麻醉诱导、清醒快等特征,对老年胃癌患者术后早期认知功能的影响不大,具有临床推广价值。
[Abstract]:Objective to investigate the effect of sevoflurane propofol combined anesthesia on early postoperative cognitive function in elderly patients with gastric cancer. Methods from February 2014 to April 2015, 80 elderly patients with gastric cancer were randomly divided into two groups: experimental group (n = 40) and control group (n = 40). Sevoflurane propofol combined anesthesia was used in the experimental group and remifentanil propofol combined anesthesia was used in the control group. The postoperative awake time, extubation time and postoperative MMSE score were compared between the two groups. Results the awake time of the experimental group (15.44 卤3.23) min, was significantly faster than that of the control group (18.73 卤3.67) min, (P0.05). The extubation time in the experimental group (22.68 卤3.75) min, was significantly faster than that in the control group (28.65 卤5.13) min, (P0.05). The MMSE scores were decreased in both groups, but the MMSE scores were (19.22 卤1.88), (21.62 卤1.57) and (27.18 卤1.13) respectively at 3 h, 6 h and 24 h after operation in the experimental group, the MMSE score and the 24 h post-operation MMSE score, respectively. The MMSE score at 72 h after operation was (24.82 卤1.77), and the MMSE score at 96 h after operation was (28.92 卤2.52). Compared with the control group, the MMSE score at 3 h after operation was (23.71 卤2.18), the MMSE score at 6 h after operation was (25.65 卤1.13), the MMSE score at 24 h after operation was (27.57 卤2.04), and the MMSE score at 72 h after operation was (26.92 卤1.83). The MMSE score at 96 h after operation was (27.26 卤1.93) in the experimental group, and the effect of the experimental group was better than that in the control group (P0.05). Conclusion combined anesthesia with sevoflurane and propofol has the advantages of rapid waking time, extubation time and low MMSE score after operation. Sevoflurane can affect the formation of LTP in hippocampus, and it has the characteristics of anesthesia induction and rapid awakening. It has little effect on early postoperative cognitive function in elderly patients with gastric cancer, and has clinical value.
【作者单位】： 内蒙古赤峰市第二医院;
【分类号】：R614;R735.2
，
本文编号：2468811
[Abstract]:Objective to investigate the effect of sevoflurane propofol combined anesthesia on early postoperative cognitive function in elderly patients with gastric cancer. Methods from February 2014 to April 2015, 80 elderly patients with gastric cancer were randomly divided into two groups: experimental group (n = 40) and control group (n = 40). Sevoflurane propofol combined anesthesia was used in the experimental group and remifentanil propofol combined anesthesia was used in the control group. The postoperative awake time, extubation time and postoperative MMSE score were compared between the two groups. Results the awake time of the experimental group (15.44 卤3.23) min, was significantly faster than that of the control group (18.73 卤3.67) min, (P0.05). The extubation time in the experimental group (22.68 卤3.75) min, was significantly faster than that in the control group (28.65 卤5.13) min, (P0.05). The MMSE scores were decreased in both groups, but the MMSE scores were (19.22 卤1.88), (21.62 卤1.57) and (27.18 卤1.13) respectively at 3 h, 6 h and 24 h after operation in the experimental group, the MMSE score and the 24 h post-operation MMSE score, respectively. The MMSE score at 72 h after operation was (24.82 卤1.77), and the MMSE score at 96 h after operation was (28.92 卤2.52). Compared with the control group, the MMSE score at 3 h after operation was (23.71 卤2.18), the MMSE score at 6 h after operation was (25.65 卤1.13), the MMSE score at 24 h after operation was (27.57 卤2.04), and the MMSE score at 72 h after operation was (26.92 卤1.83). The MMSE score at 96 h after operation was (27.26 卤1.93) in the experimental group, and the effect of the experimental group was better than that in the control group (P0.05). Conclusion combined anesthesia with sevoflurane and propofol has the advantages of rapid waking time, extubation time and low MMSE score after operation. Sevoflurane can affect the formation of LTP in hippocampus, and it has the characteristics of anesthesia induction and rapid awakening. It has little effect on early postoperative cognitive function in elderly patients with gastric cancer, and has clinical value.
【作者单位】： 内蒙古赤峰市第二医院;
【分类号】：R614;R735.2
，
本文编号：2468811
本文链接：https://www.wllwen.com/yixuelunwen/mazuiyixuelunwen/2468811.html
最近更新
教材专著
