不同药物抑制芬太尼诱导全身麻醉诱导期呛咳反应的效果比较

发布时间：2019-05-17 08:12

【摘要】：目的比较不同药物抑制芬太尼诱导全身麻醉诱导期呛咳反应的效果。方法选取2013年2月~2014年12月在我院麻醉科行全身麻醉的患者304例为研究对象,将其分为D组、L组、LD组与对照组,各76例。所有患者进入手术室后均接受血氧饱和度、脉搏、无创血压、心电图等生命指标检测,开放上肢静脉通路,并给予氯化钠注射液500 ml/h;均采用气管插管全身麻醉,静脉给予芬太尼进行麻醉诱导;D组、L组、LD组、对照组患者分别于诱导前10 min给予地塞米松、利多卡因、地塞米松及利多卡因、生理盐水。比较四组患者的呛咳反应情况。结果 D组、L组、LD组的呛咳发生率均低于对照组,LD组呛咳发生率均低于D组、L组,差异均有统计学意义(P0.05);四组患者出现严重窦性心动过速、低血压等不良反应的发生率比较,差异无统计学意义(P0.05)。结论地塞米松、利多卡均对芬太尼诱发的呛咳反应有抑制作用,联合使用效果要优于单独使用,且无严重不良反应,值得临床推广应用。
[Abstract]:Objective to compare the inhibitory effects of different drugs on cough induced by fentanyl during induction of general anesthesia. Methods from February 2013 to December 2014, 304 patients undergoing general anesthesia in anesthesia department of our hospital were divided into D group, L group, LD group and control group, 76 cases in each group. After entering the operating room, all patients received blood oxygen saturation, pulse, noninvasive blood pressure, electrocardiogram and other life indexes, opened the upper limb venous pathway, and gave sodium chloride injection 500 ml/h;. The patients in group D, group L, group LD and control group were treated with dexamethasone, lidocaine, dexamethasone, lidocaine and saline 10 min before induction, and the patients in group D, group L, group Lidocaine and control group were given dexamethasone, lidocaine, dexamethasone, lidocaine and saline 10 min before induction. The cough response of the four groups was compared. Results the incidence of cough in group D, group L and group LD was lower than that in control group, and the incidence of cough in group LD was lower than that in group D and group L, the difference was statistically significant (P 0.05). There was no significant difference in the incidence of severe sinus tachycardia, hypotension and other adverse reactions among the four groups (P 0.05). Conclusion Dexamethasone and lidocaine can inhibit the cough reaction induced by fentanyl, and the effect of combined use is better than that of fentanyl alone, and there is no serious adverse reaction, so it is worth popularizing and applying in clinic.
【作者单位】：石家庄市妇幼保健院麻醉科;
【分类号】：R614.2

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