帕瑞昔布钠对老年恶性肿瘤患者术后自控静脉镇痛的影响

发布时间：2019-05-29 16:04

【摘要】：目的探讨帕瑞昔布钠对老年恶性肿瘤患者术后舒芬太尼镇痛效果的影响。方法择期在全麻下行肿瘤根治术的患者40例,随机均分为帕瑞昔布钠组(观察组)和生理盐水组(对照组)。观察组麻醉诱导前静注40 mg帕瑞昔布钠(稀释成4 ml),对照组静注生理盐水4 ml,术毕即连接并启动电子静脉镇痛泵。观察两组患者术后1、4、8、12、24 h的视觉疼痛评分法(VAS)疼痛强度评分、Ramsay镇静评分,术后12、24 h舒芬太尼用量、病人自控静脉镇痛(PCIA)有效按压次数及不良反应。结果观察组病人术后1、4、8、12 h VAS评分和4、8、12、24 h PCIA有效按压次数小于对照组(P0.05);观察组病人术后12、24 h舒芬太尼用量显著少于对照组(P0.05);两组Ramsay镇静评分、不良反应发生率差异均无统计学意义(P0.05)。结论静注帕瑞昔布钠40 mg用于老年恶性肿瘤患者术后镇痛既可增强舒芬太尼PCIA的镇痛效应,又可以减少舒芬太尼的用量。
[Abstract]:Objective to investigate the effect of parexib sodium on postoperative sufentanil analgesia in elderly patients with malignant tumor. Methods 40 patients undergoing radical tumor resection under general anesthesia were randomly divided into two groups: observation group (observation group) and saline group (control group). In the observation group, 40 mg parexib sodium was injected intravenously before anesthesia induction (diluted into 4 ml), control group, 4 ml, saline was injected intravenously at the end of operation and the electronic intravenous analgesia pump was activated. The visual pain score (VAS) pain intensity score, Ramsay sedation score, sufentanil dosage 24 hours after operation, effective pressing times and adverse reactions of (PCIA) in patient-controlled intravenous analgesia were observed at 1, 4, 8, 12 and 24 hours after operation. Results the effective compression times of PCIA in the observation group were lower than those in the control group at 1 h, 4 h, 8 h, 12 h and 24 h after operation, and the dosage of sufentanil at 24 h in the observation group was significantly lower than that in the control group (P 0.05). There was no significant difference in Ramsay sedation score and adverse reaction rate between the two groups (P 0.05). Conclusion intravenous injection of parexib sodium 40 mg for postoperative analgesia in elderly patients with malignant tumor can not only enhance the analgesic effect of sufentanil PCIA, but also reduce the dosage of sufentanil.
【作者单位】：吉林大学第二医院麻醉科;吉林省肿瘤医院麻醉科;
【分类号】：R614;R730.5

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