不同剂量舒芬太尼对患儿心脏手术麻醉中血流动力学及术后应激反应的影响
发布时间：2019-06-18 08:46
【摘要】：目的:探讨不同剂量舒芬太尼对先天性心脏病患儿心脏手术麻醉中血流动力学以及术后应激反应的影响。方法:40例行室缺修补的患儿按随机数字表法分为A、B、C、D组,各10例。A、B、C、D组患儿麻醉诱导时分别静脉注射舒芬太尼浓度为0.6、0.8、1.0、1.2μg/kg。记录4组患儿入室诱导前(T_1)、诱导后(T_2)、插管即刻(T_3)、插管后2 min(T_4)、插管后5 min(T_5)、插管后10 min(T_6)的心率(HR)和收缩压(SBP)及入室时(t_1)、插管后(t__2)、劈胸骨后(t_3)、复温开始时(t_4)、停机后10 min(t_5)、术后24 h(t_6)各时刻乙酰胆碱(ACH)、皮质醇、胰高血糖素、白介素(IL)-6、乳酸水平。结果:4组患儿HR、SBP水平组间比较,T_1时刻差异无统计学意义(P0.05),T_2~T_6各时刻差异均有统计学意义(P0.05);4组患儿ACH、胰高血糖素、IL-6、乳酸水平组间比较,T_1时刻差异无统计学意义(P0.05),T_2~T_6时刻差异均有统计学意义(P0.05);皮质醇水平在t_1~t_4时刻差异无统计学意义(P0.05),t_5~t_6时刻差异有统计学意义(P0.05)。结论:小儿心脏手术麻醉中,选择舒芬太尼的剂量以1.0μg/kg最为适宜,对患儿血流动力学和术后应激反应的影响较小。
[Abstract]:Objective: To investigate the effects of different dose of sufentanil on hemodynamics and post-operative stress response in children with congenital heart disease. Methods:40 children with ventricular septal defect were divided into groups A, B, C and D according to the random number table method. The concentrations of sufentanil in group A, B, C and D were 0.6, 0.8, 1.0 and 1.2. m The rate of heart rate (HR) and systolic blood pressure (SBP) and blood pressure (t _ 1), post-intubation (t _ 2) and sternal time (t _ 3) were recorded in 4 groups (T _ 1), after induction (T _ 2), immediate (T _ 3),2 min (T _ 4),5 min (T _ 5) after intubation,10 min (T _ 6) after intubation, and (t _ 1), after intubation (t _ 2), after the sternal incision (t _ 3), At the beginning of rewarming (t _ 4), after the shutdown,10 min (t _ 5) and 24 h (t _ 6) at the end of the operation, the levels of acetylcholine (ACH), cortisol, glucagon, interleukin (IL)-6, and lactic acid were observed at the time of 24 h (t _ 6). Results: The levels of HR and SBP in four groups were not significant (P0.05), and the difference of T _ 2 and T _ 6 was statistically significant (P0.05). There was no significant difference in the time of T _ 2 ~ T _ 6 (P0.05). There was no significant difference between the time of t _ 1 ~ t _ 4 and the difference of t _ 5 ~ t _ 6 at the time of t _ 1 ~ t _ 4 (P <0.05). Conclusion: The dosage of sufentanil is the most suitable for pediatric cardiac surgery, and the effect of sufentanil on hemodynamics and post-operative stress response in children is less.
【作者单位】： 江苏省睢宁县人民医院麻醉科;
【分类号】：R726.1
本文编号：2501339
[Abstract]:Objective: To investigate the effects of different dose of sufentanil on hemodynamics and post-operative stress response in children with congenital heart disease. Methods:40 children with ventricular septal defect were divided into groups A, B, C and D according to the random number table method. The concentrations of sufentanil in group A, B, C and D were 0.6, 0.8, 1.0 and 1.2. m The rate of heart rate (HR) and systolic blood pressure (SBP) and blood pressure (t _ 1), post-intubation (t _ 2) and sternal time (t _ 3) were recorded in 4 groups (T _ 1), after induction (T _ 2), immediate (T _ 3),2 min (T _ 4),5 min (T _ 5) after intubation,10 min (T _ 6) after intubation, and (t _ 1), after intubation (t _ 2), after the sternal incision (t _ 3), At the beginning of rewarming (t _ 4), after the shutdown,10 min (t _ 5) and 24 h (t _ 6) at the end of the operation, the levels of acetylcholine (ACH), cortisol, glucagon, interleukin (IL)-6, and lactic acid were observed at the time of 24 h (t _ 6). Results: The levels of HR and SBP in four groups were not significant (P0.05), and the difference of T _ 2 and T _ 6 was statistically significant (P0.05). There was no significant difference in the time of T _ 2 ~ T _ 6 (P0.05). There was no significant difference between the time of t _ 1 ~ t _ 4 and the difference of t _ 5 ~ t _ 6 at the time of t _ 1 ~ t _ 4 (P <0.05). Conclusion: The dosage of sufentanil is the most suitable for pediatric cardiac surgery, and the effect of sufentanil on hemodynamics and post-operative stress response in children is less.
【作者单位】： 江苏省睢宁县人民医院麻醉科;
【分类号】：R726.1
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1 乌伟光;新生儿术后应激反应的研究[J];中华小儿外科杂志;2002年02期
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