脑灌注成像技术的应用研究进展

发布时间：2019-08-03 08:24

【摘要】：脑灌注成像检查对于缺血性脑卒中的评估至关重要,其作用贯穿于缺血性脑卒中的各个时期。不同脑灌注成像检查方法的优缺点各异。CT灌注成像(CTP)具有普及率高、操作简便、扫描时间短、后处理简便、获得数据快等优点,缺点是CTP的各参数阈值没有一个统一指标、扫描层面受限、结果再现性还有待证实、仍有辐射等。氙气增强CT有无创、计算精度高等优点,缺点是结果易受呼吸节律的影响、氙气有麻醉作用。动态磁敏感对比增强磁共振灌注成像的优势是能够进行多层面成像,且获得参数全面,但缺点是需使用含钆对比剂。动脉自旋标记无需注射对比剂,完全无创,可反复检查,但只能获得脑血流量一个参数。正电子发射体层成像、单光子发射计算机断层成像是无创、准确、参数全面的灌注检查,但需要昂贵的检查费用和复杂的操作。多普勒超声造影的优势在于实时、无创、快速、安全,其局限性在于图像分辨率较低。
[Abstract]:Cerebral perfusion imaging is very important for the evaluation of ischemic stroke, and its role runs through all stages of ischemic stroke. The advantages and disadvantages of different cerebral perfusion imaging methods are different. Ct perfusion imaging (CTP) has the advantages of high popularity, simple operation, short scanning time, simple post-processing, fast data acquisition and so on. The disadvantage is that there is no unified index of each parameter threshold of CTP, the scanning level is limited, the reproducibility of the results still needs to be confirmed, and there is still radiation and so on. Xenon enhanced CT has the advantages of noninvasive and high calculation accuracy, but the disadvantage is that the results are easily affected by respiratory rhythm, and Xenon has anesthetic effect. The advantage of dynamic magnetic sensitivity contrast enhanced magnetic resonance perfusion imaging is that it can perform multiplanar imaging and obtain comprehensive parameters, but the disadvantage is that gadolinium containing contrast agent is needed. Arterial spin labeling does not require injection of contrast agent, is completely noninvasive and can be examined repeatedly, but only one parameter of cerebral blood flow can be obtained. Positron emission tomography (PET) is a noninvasive, accurate and comprehensive perfusion examination, but it requires expensive inspection cost and complex operation. The advantage of Doppler contrast-enhanced ultrasound is real-time, non-invasive, fast and safe, and its limitation lies in the low resolution of the image.
【作者单位】：内蒙古医科大学;内蒙古医科大学附属医院;
【分类号】：R743.3

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