脾脏通过上调肝PTEN/Akt通路延缓大鼠NAFLD进展
发布时间：2021-04-19 08:18
[背景]脾脏是机体最大的外周免疫器官,脾脏在机体免疫、抗感染、血液滤过等方面起着重要的作用,从脾切除术后凶险性感染的发现开始,脾脏越来越得到人们的重视,脾脏对机体其他方面的重要作用也渐渐被发现。研究显示脾脏在机体脂质代谢中起着重要作用,脾脏可以降低血脂水平,脾切除术后血脂水平升高。酒精性脂肪性肝病（NAFLD）以肝细胞脂质蓄积为主要特征,包括简单肝细胞脂肪变性、非酒精性脂肪性肝炎（NASH）以及其发展到严重阶段的肝硬化甚至肝癌发生等一系列肝脏疾病表现。流行病学显示NAFLD在全球,尤其是发达国家的患病率越来越高,已成为严重危害人类健康的杀手。脾脏跟肝脏解剖学上相邻,脾脏在许多肝脏疾病的发生发展中扮演着重要的角色,脾脏分泌的生物活性物质可通过门静脉血流进入肝脏,影响肝脏疾病的进展与预后,比如脾源性的TGF-beta在脾脏促进肝纤维化发展过程中起着重要作用。研究显示,非酒精性脂肪性肝病的大鼠模型中行脾脏切除的大鼠肝脏脂肪变、肝组织甘油三酯及一些不饱和脂肪酸含量明显高于假手术组。这说明,在NAFLD的发生发展过程中,脾脏起到了减缓进展的作用,切除脾脏后NAFLD进展加快。但其作用机制还不清楚...
【文章来源】：南方医科大学广东省
【文章页数】：72 页
【学位级别】：硕士
【部分图文】：
图３－５－１?ＰＴＥＮ基因及Ａｋｔ、ｐＡｋｔ检测结果??
３．４血脂水平检测结果??血脂水平是脂质代谢素乱的特点之一，本实验采用全自动化学分析仪检测??各姐血脂水平，结果见直方图３－４－１．统计结果显示，Ｄ姐与Ｃ组血ＴＣ、ＴＧ、??ＬＤＬ、ＶＬＤＬ浓度明显高于Ｂ组与Ａ组；Ｂ姐巧Ａ组比较，血清ＴＣ、ＬＤＬ、??ＶＬＤＬ浓度由显著差异（Ｂ＞Ａ），而Ｄ组与Ｃ组比较，血清ＴＣ、ＬＤＬ浓度有明??显差异。见图３－４－２．??巧ｒｕｍ?ＬＤＬ（ｍｇ／ｄＬ）?巧化ｍ?Ｔ（３（ｍｇ／ｄＬ）?巧ｒｕｍ?ＨＤＭｍｇＷＬ｝??＂１?ｔ＊?，＂１?＂Ｉｔ?ｔ?。Ｓｈａｍ??＂＾?ｔ？?Ｊ?ｐＬ?了?因?ｓｐｘ??４０．?－ｋ?ｊＬ?１?放．?二?２０－?ｒｎ??Ｔ?ｆｔ?ｎ；??２０－?助．?＇＇?１０－??山ｕ?Ｉ?ｉ，ｙ?〇ｉ?ｉ．ｉ．．．．．．?ｙ：ｊ?ｊ?Ｉ?Ｉ?ｉ，ｕ??今?参?麥?姜?參?夺＊??ｓｅｒｕｍ?ＴＣ（ｍｇ／ｄＬ）?ｓｅｒｕｍ?ＶＬＤＬ（ｍｇ／ｄＬ）??１Ｓ〇１?４０－１?苦??＃＊?？■?＊??Ａ?円；：－?Ａ?ｈ?Ｉ?Ｉ??Ｍ．円，?＇?Ａ?＇鑛??」Ｉ?ＩＭ?ＩＩ?ｂＪ?，１１?ＩＩ＇！?Ｉ?ＩＭ??
【参考文献】：
期刊论文
[1]Expression of PTEN,PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues[J]. Shu-Kun Wu, Bao-Ju Wang, Xi-Ping Zhao, Dong-Liang Yang, Division of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Yan Yang, Dong-Liang Yang, Center of Experimental Medicine Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Xin-Hua Feng, Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, TX 77030, United States Shu-Kun Wu, Department of infectious Disease, Hubei Province Corps Hospital, The Chinese People’s Armed Police Forces, Wuhan 430061, Hubei Province, China. World Journal of Gastroenterology. 2007(34)
[2]Cyclooxygenases in hepatocellular carcinoma[J]. Melchiorre Cervello,Giuseppe Montalto. World Journal of Gastroenterology. 2006(32)
本文编号：3147191
【文章来源】：南方医科大学广东省
【文章页数】：72 页
【学位级别】：硕士
【部分图文】：
图３－５－１?ＰＴＥＮ基因及Ａｋｔ、ｐＡｋｔ检测结果??
３．４血脂水平检测结果??血脂水平是脂质代谢素乱的特点之一，本实验采用全自动化学分析仪检测??各姐血脂水平，结果见直方图３－４－１．统计结果显示，Ｄ姐与Ｃ组血ＴＣ、ＴＧ、??ＬＤＬ、ＶＬＤＬ浓度明显高于Ｂ组与Ａ组；Ｂ姐巧Ａ组比较，血清ＴＣ、ＬＤＬ、??ＶＬＤＬ浓度由显著差异（Ｂ＞Ａ），而Ｄ组与Ｃ组比较，血清ＴＣ、ＬＤＬ浓度有明??显差异。见图３－４－２．??巧ｒｕｍ?ＬＤＬ（ｍｇ／ｄＬ）?巧化ｍ?Ｔ（３（ｍｇ／ｄＬ）?巧ｒｕｍ?ＨＤＭｍｇＷＬ｝??＂１?ｔ＊?，＂１?＂Ｉｔ?ｔ?。Ｓｈａｍ??＂＾?ｔ？?Ｊ?ｐＬ?了?因?ｓｐｘ??４０．?－ｋ?ｊＬ?１?放．?二?２０－?ｒｎ??Ｔ?ｆｔ?ｎ；??２０－?助．?＇＇?１０－??山ｕ?Ｉ?ｉ，ｙ?〇ｉ?ｉ．ｉ．．．．．．?ｙ：ｊ?ｊ?Ｉ?Ｉ?ｉ，ｕ??今?参?麥?姜?參?夺＊??ｓｅｒｕｍ?ＴＣ（ｍｇ／ｄＬ）?ｓｅｒｕｍ?ＶＬＤＬ（ｍｇ／ｄＬ）??１Ｓ〇１?４０－１?苦??＃＊?？■?＊??Ａ?円；：－?Ａ?ｈ?Ｉ?Ｉ??Ｍ．円，?＇?Ａ?＇鑛??」Ｉ?ＩＭ?ＩＩ?ｂＪ?，１１?ＩＩ＇！?Ｉ?ＩＭ??
【参考文献】：
期刊论文
[1]Expression of PTEN,PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues[J]. Shu-Kun Wu, Bao-Ju Wang, Xi-Ping Zhao, Dong-Liang Yang, Division of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Yan Yang, Dong-Liang Yang, Center of Experimental Medicine Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Xin-Hua Feng, Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, TX 77030, United States Shu-Kun Wu, Department of infectious Disease, Hubei Province Corps Hospital, The Chinese People’s Armed Police Forces, Wuhan 430061, Hubei Province, China. World Journal of Gastroenterology. 2007(34)
[2]Cyclooxygenases in hepatocellular carcinoma[J]. Melchiorre Cervello,Giuseppe Montalto. World Journal of Gastroenterology. 2006(32)
本文编号：3147191
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