XRCC1和XRCC3基因多态性与膀胱癌发病风险的相关性

发布时间：2018-01-02 22:04

本文关键词：XRCC1和XRCC3基因多态性与膀胱癌发病风险的相关性　出处：《实用医学杂志》2016年03期 　论文类型：期刊论文

更多相关文章： 膀胱肿瘤 XRCC XRCC 基因多态性

【摘要】：目的:研究DNA修复基因XRCC1(rs25487)和XRCC3(rs1799796)的单核苷酸多态性与膀胱癌易感性及其病理参数的相关性。方法:采用病例-对照研究方法,收集经病理诊断为膀胱癌患者的279例为病例组,健康体检正常的人群280例为对照组,采用限制性片段长度多态性-聚合酶链式反应(PCR-RFLP)技术检测多态性位点rs25487和rs1799796在病例组和对照组中的基因型分布。采用Logistic回归模型分析各基因型与膀胱癌发生的关系并比较不同基因型与膀胱癌及其病理参数的关系。结果:XRCC1(rs25487)和XRCC3(rs1799796)位点在病例及对照组中分布无统计学差异(均P0.05);rs25487的AG基因型在肿瘤分期Ⅰ-Ⅱ期(OR=0.48,95%CI=0.31~0.73)、高分化(OR=0.53,95%CI=0.29~0.97)、低分化(OR=0.56,95%CI=0.33~0.94)、无周围淋巴结转移组(OR=0.53,95%CI=0.34~0.84)、无远端淋巴结转移组(OR=0.56,95%CI=0.37~0.83)中的分布频率低于对照组;rs1799796的GG基因型在中分化(OR=3.68,95%CI=1.62~8.36)、有周围淋巴结转移组(OR=2.36,95%CI=1.23~4.53)及有远端淋巴结转移组(OR=2.51,95%CI=1.08~5.80)中的分布频率高于对照组,使膀胱癌的发病风险增加。结论:本研究发现XRCC1(rs25487)和XRCC3(rs1799796)与膀胱癌的病理进展相关。
[Abstract]:Objective: To study the DNA repair gene XRCC1 (rs25487) and XRCC3 (rs1799796) the correlation between single nucleotide polymorphism and susceptibility of bladder cancer and its clinicopathological parameters. Methods: a case-control study, collected by the pathological diagnosis of patients with bladder cancer, 279 cases and 280 cases of normal healthy people as control group. Using restriction fragment length polymorphism polymerase chain reaction (PCR-RFLP) genotype distribution in cases and controls the detection of polymorphisms of rs25487 and rs1799796. Logistic regression model was used to analyze the relationship between the genotype and the occurrence of bladder cancer and the relationship between the genotype and bladder cancer and its pathological parameters. Results: XRCC1 (rs25487) and XRCC3 (rs1799796) sites in the case and control group no significant difference in the distribution of (P0.05); AG gene rs25487 in tumor stage I-II stage (OR=0.48,95%CI=0.31~ 0.73), high differentiation (OR=0.53,95%CI=0.29~0.97), low differentiation (OR=0.56,95%CI=0.33~0.94), no lymph node metastasis group (OR=0.53,95%CI=0.34~0.84), no distal lymph node metastasis (OR=0.56,95%CI=0.37~0.83) distribution in frequency is lower than the control group; GG genotype of rs1799796 in differentiation (OR=3.68,95%CI=1.62~8.36), peripheral lymph node metastasis group (OR=2.36,95%CI=1.23~4.53) and a distal lymph node metastasis (OR=2.51,95%CI=1.08~5.80) in the distribution frequency was higher than the control group, the incidence of bladder cancer risk increased. Conclusion: This study found that XRCC1 (rs25487) and XRCC3 (rs1799796) and pathological progress of bladder cancer.

【作者单位】：南京大学医学院附属鼓楼医院核医学科;南京医科大学附属南京医院核医学科;
【分类号】：R737.14
【正文快照】： 膀胱癌是泌尿系统常见的恶性肿瘤之一,其发生是一个多因素、多步骤的复杂过程,特别是一些外源性的诱变剂或致癌物引起一系列DNA损伤是导致膀胱癌的重要原因。 DNA修复系统是机体内的重要防御屏障。研究[1]结果表明, DNA修复酶基因的多态性可改变DNA修复酶蛋白含量或活性,导致D

【相似文献】