伐地那非降阶梯治疗男性勃起功能障碍的效果分析

发布时间：2018-01-27 17:00

本文关键词： 伐地那非男性勃起功能障碍疗效副反应　出处：《第三军医大学学报》2015年15期 　论文类型：期刊论文

【摘要】：目的观察逐渐降低伐地那非剂量治疗男性勃起功能障碍(erectile dysfunction,ED)的疗效。方法 65例初治ED患者,分别给予20、10、5 mg(A、B、C 3个阶段)的伐地那非降阶梯序贯疗法,每个阶段治疗时间为1个月。结果 3阶段组患者治疗后国际勃起功能指数(international index of erectile function,IIEF)均高于治疗前(P0.05)。A、B、C 3阶段患者日记记录插入成功率分别为78.1%、75.9%、69.1%;完成性交的成功率分别为74.9%、70.7%、66.9%,均高于治疗前(P0.05)。A、B、C 3阶段药物副反应发生率分别为56.9%、29.2%、26.2%,A阶段明显高于B、C阶段(P0.05)。结论伐地那非减低到中、低剂量时,能够在保证疗效的基础上,显著减少药物副反应的发生。
[Abstract]:Objective to observe the effect of gradually decreasing valdenafil dose on erectile dysfunctional EDV in male erectile dysfunction. Methods 65 patients with primary Ed were treated. The patients were given 10 ~ 10 ~ 5 mg / g Agna BU C (3 stages) of vardenafil step descending sequential therapy respectively. Results the international erectile function index (IPI) in the three-stage group after treatment was 1 month. International index of erectile function. IIEFs were higher than those before treatment (P 0.05). The successful rate of insertion of diaries was 78.1% and 75.9% (P < 0.05), respectively, and 69.1% (P < 0.05). The successful rate of accomplishing sexual intercourse was 74.9 and 70.7, respectively, which was higher than that of P0.05. Abub C 3 before treatment. The incidences of side effects were 56.9% respectively. 29.2 / 26.2A stage was significantly higher than that of BPC stage P0.050.Conclusion when the dosage of vardenafil is reduced to middle and low dose, it can be based on the guarantee of curative effect. [WT5 "HZ] [WT5" HZ] [WT5 "HZ]. The incidence of side effects was significantly reduced.
【作者单位】：重庆市中山医院泌尿外科;
【分类号】：R698.1
【正文快照】： 勃起功能障碍(erectile dysfunction,ED)是指阴茎不能达到或维持持续的勃起,以获得满意的性生活。目前,磷酸二酯酶5(phosphodiesterase type 5 inhibitor,PDE5)抑制剂是治疗该病的主要药物之一,其中伐地那非是新一代PDE5抑制剂,选择性更高[1]。伐地那非于2004年9月16日正式获

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