肾移植后颈总动脉形态及其衰老进程

发布时间：2018-01-31 16:44

本文关键词： 肾移植终末期肾病颈总动脉形态学衰老超声　出处：《复旦学报(医学版)》2017年03期 　论文类型：期刊论文

【摘要】：目的分析肾移植患者颈总动脉形态学参数随年龄变化的斜率,探讨其衰老进程。方法 31例肾移植患者(kidney transplant recipient,KTR),31例维持性血透的终末期肾病(end-stage renal disease,ESRD)患者,84例年龄、性别匹配的对照接受颈动脉超声检查。测量右颈总动脉内-中膜厚度(carotid intima-media thickness,CIMT)和右颈总动脉管径(common carotid artery diameter,CCAD)。CIMT和CCAD随年龄变化的斜率采用线性回归分析。结果 ESRD组患者与KTR组和对照组比较,CIMT增厚,CCAD增宽(P0.05)。KTR组和对照组之间CIMT和CCAD差异无统计学意义(P0.05)。CIMT与年龄呈正相关(P0.05)。CIMT随年龄变化的斜率(回归系数b):对照组大于KTR组和ESRD组(Z=1.417,P=0.006;Z=2.223,P0.001),KTR组和ESRD组之间的差异无统计学意义(Z=1.038,P=0.723)。CCAD与年龄呈正相关(P0.05)。CCAD随年龄变化的斜率:ESRD组小于对照组(Z=1.677,P=0.002)。结论肾移植患者颈总动脉形态学部分改善,血管衰老逐步恢复自然进程。
[Abstract]:Objective to analyze the slope of the morphological parameters of common carotid artery in renal transplantation patients with age. Methods Thirty one patients with renal transplantation were enrolled in this study. There were 31 patients with end-stage renal disease (ESRD) with maintenance hemodialysis. Carotid ultrasound was performed in the sex-matched control group. The medial thickness of the right common carotid artery was measured and carotid intima-media thickness was measured. CIMT) and the common carotid artery diameter of the right common carotid artery. The slope of CCAD).CIMT and CCAD with age was analyzed by linear regression analysis. Results the patients in ESRD group were thicker than those in KTR group and control group. There was no significant difference in CIMT and CCAD between P0.05U 路KTR group and control group (P 0.05). CIMT was positively correlated with age (P0.05). The slope of CIMT with age (regression coefficient btr: the control group was larger than KTR group and ESRD group). P0. 006; There was no significant difference between the KTR group and ESRD group. There was a positive correlation between P0. 05 and CCAD. The slope of P0. 05. CCAD with age was smaller in the ESRD group than that in the control group (Z0. 677). Conclusion the morphology of common carotid artery in renal transplantation patients was improved, and vascular aging was gradually restored to natural process.
【作者单位】：上海交通大学附属第一人民医院超声科;上海交通大学附属第一人民医院泌尿科;上海交通大学附属第一人民医院心超室;
【基金】：上海市科学技术委员会医学引导类科技项目(15411969100,16411969300) 上海市卫生和计划生育委员会基金(201440290,201640043) 上海交通大学医工交叉研究基金(YG2015MS28)~~
【分类号】：R445.1;R699.2
【正文快照】： 上海市科学技术委员会医学引导类科技项目(15411969100,16411969300);上海市卫生和计划生育委员会基金(201440290,201640043);上海交通大学医工交叉研究基金(YG2015MS28)△Corresponding author E-mail:lxh_20050703@sina.com维持性血透的终末期肾病(end-stage renaldisease,E

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