体外试验模拟肾结石溶解治疗的反应动力学

发布时间：2018-02-04 10:18

本文关键词： 泌尿系结石化学溶解人造模型反应动力学　出处：《实用医学杂志》2017年16期 　论文类型：期刊论文

【摘要】：目的探索结石溶解溶液在模拟人体环境下溶解结石过程中的反应动力学规律,为临床应用提供参考。方法制备模拟人体上尿路结构的硅胶模型。利用笔者前期研究制备的乳酸溶液,在模型中模拟溶解人工结石,定时测取溶出液中产物的浓度,了解反应进行的速度规律与溶解液流速、反应物表面积等参数的关系。结果溶液利用率在100~150 mL/h范围最优。溶解效率与结石表面积正相关。在50~400 mL/h流速范围内,总溶出效率随溶液流速而增大。结论结石溶解液临床应用时,前期治疗应尽可能粉碎结石,增加其表面积,在允许的情况下宜采用较高的灌流速度以达到尽快溶解结石的目的。
[Abstract]:Objective to explore the kinetics of dissolution of stones in simulated human environment. Methods the silica gel model was made to simulate the structure of human upper urinary tract. The lactic acid solution prepared by the author was used to simulate the dissolution of artificial stones in the model. The concentration of the product in the dissolution solution was measured at regular time to understand the law of the reaction speed and the flow rate of the solution. Results the solution utilization ratio was optimal in the range of 100g ~ 150 mL/h. The dissolution efficiency was positively correlated with the surface area of stone. The flow rate was 50 ~ 400 mL/h. Conclusion in clinical application of lithiasis solution, the early treatment should be as much as possible to crush the stone and increase its surface area. In order to dissolve the stones as soon as possible, it is advisable to use high perfusion speed.
【作者单位】：南方医科大学附属小榄医院泌尿外科;
【基金】：中山市科技计划项目基金资助(编号:2014A1FC120)
【分类号】：R692.4
【正文快照】： 化学溶石方法由来已久,是针对泌尿系结石的一种不容忽视的治疗方式,有其独特优势。溶解液通过与结石成分化学反应,使结石成分重新溶解在液相中,随着液体被带出体外。由于液体的流动性和溶液成分的可扩散性,较各种手术手段更容易到达肾脏的各个角落,不容易有治疗死角,因而处理

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