尿膀胱肿瘤抗原在膀胱癌中的表达及意义

发布时间：2018-02-05 21:59

本文关键词： 酶联免疫吸附法膀胱肿瘤抗原膀胱癌尿脱落细胞学　出处：《中国现代医学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨膀胱肿瘤抗原(BTA)的临床应用价值。方法收集46例膀胱癌、35例泌尿系良性疾病、10例健康者尿液,同时做尿脱落细胞学及BTA检测。结果 (1)BTA检测的敏感性为86.9%,特异性为82.2%,假阳性率为17.8%(95%CI:0.759,0.924);尿脱落细胞学检测的敏感性为34.7%,特异性为97.8%,假阳性率为2.2%(95%CI:0.550,0.775);(2)BTA表达水平和敏感性与肿瘤分级分期、有无肉眼血尿有关(P0.05),与复发或初发无关(P0.05);BTA对各级、各期的膀胱癌的敏感性均高于尿脱落细胞学检测(P0.05);(3)BTA在早期膀胱癌(Ta~T1期)中表达水平高于良性疾病组、健康组(P0.05)。结论 BTA对膀胱癌的诊断、早期筛查及跟踪随访有较高的临床应用价值,但应注意血尿影响BTA检测结果。
[Abstract]:Objective to evaluate the clinical value of bladder tumor antigen (BTAA). Methods urine samples from 35 patients with bladder cancer and 10 healthy controls were collected. Urine exfoliative cytology and BTA were performed simultaneously. Results the sensitivity and specificity of BTA were 86.9 and 82.2% respectively. The false positive rate was 17. 8% and 95%, including 0. 759% and 0. 924%. The sensitivity, specificity and false positive rate of urine exfoliative cytology were 34.7 and 97.8.The false positive rate was 2.2and 95 CI: 0.550 / 0.775; The expression level and sensitivity of BTA were correlated with tumor grade and stage, with or without gross hematuria (P0.05A), and had no relation with recurrence or initial onset (P0.05A). The sensitivity of BTA to bladder cancer at all stages was higher than that of urine exfoliative cytology (P0.05). The expression of BTA in the early stage of bladder cancer was higher than that in the benign group. Conclusion BTA is useful in the diagnosis of bladder cancer. Early screening and follow-up have high clinical value, but we should pay attention to the influence of hematuria on the results of BTA.
【作者单位】：广西医科大学附属肿瘤医院;
【分类号】：R737.14

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