老年人群24小时动态血压变异性与肾功能损害的关系

发布时间：2018-02-19 18:27

本文关键词： 老年人群血压变异性肾小球滤过率收缩压标准差　出处：《中国动脉硬化杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨老年人群24 h动态血压变异性与肾功能损害的关系。方法在参加开滦研究队列第三次健康体检的人群中,采取整群抽样的方法随机抽取3064例年龄≥60岁的开滦集团离退休员工,对其进行动态血压监测,最终纳入统计分析的为1382例。根据动态收缩压的标准差(SSD)四分位数将调查人群分为四组,测定各项生化指标,计算肾小球滤过率(eGFR),采用秩相关分析和逐步线性回归模型分析SSD与eGFR的关系。结果在1382例观察对象中,平均年龄为67.16±5.86岁,其中,男性905例(65.5%),女性477例(34.5%)。24h SSD、日间SSD和夜间SSD均与eGFR呈负相关;对e GFR的影响因素进行逐步线性回归分析,校正其他混杂因素后,24h SSD、日间SSD仍与e GFR呈负线性相关。结论 24h SSD和日间SSD与eGFR呈负线性相关。
[Abstract]:Objective to investigate the relationship between 24 h ambulatory blood pressure variability and renal dysfunction in elderly people. A cluster sampling method was used to randomly select 3064 retired employees of Kailuan Group, aged more than 60 years, and to monitor their ambulatory blood pressure. 1382 cases were included in the statistical analysis. According to the quartile number of SSDs of dynamic systolic blood pressure, the investigated population was divided into four groups, and the biochemical indexes were measured. The relationship between SSD and eGFR was analyzed by rank correlation analysis and stepwise linear regression model. Results the mean age was 67.16 卤5.86 years. In 905 cases of male, 65.5% of them, 477 cases of female had negative correlation with eGFR, day SSD and night-time SSD were negatively correlated with eGFR, and the influencing factors of eGFR were analyzed by stepwise linear regression analysis. After adjusting for other confounding factors, there was still a negative linear correlation between daytime SSD and eGFR after 24 h SSD.Conclusion 24 h SSD and daytime SSD have negative linear correlation with eGFR.
【作者单位】：开滦总医院老年病科;华北理工大学研究生院;
【分类号】：R692

【相似文献】