中青年难治性高血压患者小动脉重构与靶器官肾损伤的关系

发布时间：2018-02-27 00:14

本文关键词： 难治性高血压壁腔比桡动脉肾损伤　出处：《东南大学学报(医学版)》2017年02期 　论文类型：期刊论文

【摘要】：目的:初步探讨中青年难治性高血压(RH)患者外周小动脉重构与亚临床靶器官肾损害的关系。方法:入选中青年(18~65岁)RH、可控性高血压(CH)及血压正常(NT)者各60例。同时检测血压、桡动脉血管超声及尿微量白蛋白肌酐比(UACR)。结果:RH组UACR、外周收缩压(SBP)、舒张压(DBP)、平均动脉压(MBP)、壁腔比、周向壁应力及平均剪切力均较CH及NT组高(P0.05);调整混杂因素后,在总体人群中桡动脉壁腔比与UACR、周向壁应力呈正相关,与管壁横截面积呈负相关(P0.05);多因素线性回归分析显示,在总体人群中桡动脉壁腔比的独立影响因素为周向壁应力、DBP、SBP及UACR。结论:中青年RH患者小动脉重构程度重于CH患者,且外周小动脉重构进一步加重靶器官肾损伤。
[Abstract]:Objective: to explore the relationship between peripheral arteriole remodeling and subclinical target organ renal damage in young and middle-aged patients with refractory hypertension (RH). Methods: 60 patients with RH (controllable hypertension) and 60 patients with normal blood pressure (NTN) were enrolled in this study. Results the ratio of systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MBP), wall to lumen ratio, circumferential stress and mean shear force of the two groups were higher than those of the Ch and NT groups (P 0.05). In the whole population, the ratio of radial artery wall to lumen was positively correlated with UACRand circumferential stress, and negatively correlated with cross sectional area (P0.05A). The independent factors influencing the ratio of radial artery wall to lumen were peripheral wall stress DBPU SBP and UACR.Conclusion: the degree of arteriole remodeling in young and middle-aged RH patients is more serious than that in Ch patients, and peripheral arteriole remodeling can further aggravate the renal injury of target organs.
【作者单位】：徐州市心血管病研究所;徐州市中心医院急诊科;徐州市中心医院心内科;徐州市中心医院超声科;
【基金】：江苏省临床医学科技专项(BL2012019) 徐州市社会发展项目(XM12B062)
【分类号】：R544.1;R692

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