血清抗苗勒管激素与精液参数的相关性分析

发布时间：2018-02-27 20:28

本文关键词： 抗苗勒管激素精液参数生殖激素精子发生支持细胞　出处：《中华男科学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的:本研究旨在探讨血清抗苗勒管激素(AMH)与精液参数之间的关系。方法:收集我院2015年9月至2016年11月男性不育门诊就诊患者的资料共计726例,其中非梗阻性无精子症者72例,少精子症者123例,正常精子浓度者531例。对患者进行精液常规和血清学检测,包括精液量、精子总数、精子浓度、精子活动率、前向运动精子百分率率、正常形态精子百分率和AMH、抑制素B(Inh-B)、睾酮(T)、卵泡刺激素(FSH),整理数据进行回顾性分析。结果:血清AMH水平与精子总数(r=0.227,P0.001)、精子浓度(r=0.215,P0.001)、精子活动率(r=0.111,P=0.003)、前向运动精子百分率(r=0.120,P=0.001)、Inh-B(r=0.399,P0.001)、T(r=0.184,P=0.002)之间存在一定的正相关;与FSH(r=-0.283,P0.001)存在负相关;与年龄、禁欲时间、精液量和正常形态精子百分率之间(P0.05)均无显著相关性。非梗阻性无精子症组、少精子症组和正常组患者之间血清AMH水平有显著差异(6.33±4.26 vs 8.26±3.98 vs 9.8±5.19 ng/ml,P0.001)。结论:AMH是反映睾丸支持细胞功能的一个生物标志物;血清AMH水平与精子浓度和活动率明显相关,提示AMH可能与精子的发生和成熟有关。
[Abstract]:Objective: the purpose of this study is to investigate the serum anti Mullerian hormone (AMH) and the relationship between semen parameters. Methods: in our hospital from September 2015 to November 2016, male infertility clinic patients from a total of 726 cases, including 72 cases of non obstructive azoospermia, 123 cases of oligospermia, 531 cases of normal sperm concentration. Detection of semen and serum of patients, including semen volume, sperm count, sperm concentration, sperm motility, sperm forward movement rate, the percentage of normal sperm morphology and AMH, inhibin B (Inh-B), testosterone (T), follicle stimulating hormone (FSH), the data were retrospectively analyzed. Results: the total number of sperm and serum level of AMH (r=0.227, P0.001), sperm concentration (r=0.215, P0.001), sperm motility (r=0.111, P=0.003), sperm forward movement (r=0.120, P=0.001), Inh-B (r=0.399, P0.001), T (r=0.184, P=0.002) between the Positive correlation; and FSH (r=-0.283, P0.001) are negatively correlated; with age, abstinence time, between semen volume and the percentage of normal sperm morphology (P0.05) have no significant correlation. The non obstructive azoospermia group, less sperm group and normal group patients serum AMH level has significant difference (6.33 + 4.26 vs 8.26 + 3.98 vs 9.8 + 5.19 ng/ml, P0.001). Conclusion: AMH is a reflection of a biological marker of Sertoli cell function; the serum level of AMH was significantly correlated with sperm concentration and activities, tips and mature AMH may be related to spermatogenesis.

【作者单位】：南方医科大学附属金陵医院生殖医学中心;南京军区南京总医院生殖医学中心;
【分类号】：R698.2

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