臂踝动脉脉搏波传导速度与慢性肾脏病的关系

发布时间：2018-02-28 10:51

本文关键词： 臂踝动脉脉搏波传导速度估算的肾小球滤过率蛋白尿慢性肾脏病　出处：《中华高血压杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的臂踝动脉脉搏波传导速度(baPWV)是心血管病危险及预后的独立预测因子之一,慢性肾脏病(CKD)患者心脑血管事件增加可能与其动脉硬化有关,目前为止有关baPWV与CKD的研究结果尚不一致,本研究主要探讨baPWV与CKD的关系。方法对完成baPWV检测的观察对象19 376人进行分析,平均年龄为50.5岁,其中男性12 533人(64.8%)。CKD包括估算的肾小球滤过率(eGFR)60 mL/(min·1.73 m~2)或尿蛋白阳性。结果 CKD的发生率随baPWV(三分位)的升高而升高。在Logistic回归分析中,校正了年龄、性别等混杂因素后,以baPWV第1三分位组为对照组,第3三分位组发生eGFR60mL/(min·1.73m~2)、尿蛋白阳性或CKD的OR值(95%CI)分别为1.34(1.05~1.70)、1.67(1.27~2.16)、1.46(1.21~1.77);以baPWV每增加一个标准差为自变量,校正了多种混杂因素后,发生eGFR60mL/(min·1.73m~2)、尿蛋白阳性、CKD的OR值(95%CI)分别为1.15(1.05~1.25)、1.24(1.14~1.35)、1.20(1.13~1.29)。结论 baPWV增加与CKD的发生独立相关。
[Abstract]:Objective the brachial and malleolus pulse wave velocity (BAPWV) is one of the independent predictors of cardiovascular risk and prognosis. The increase of cardiovascular and cerebrovascular events in patients with chronic kidney disease may be related to arteriosclerosis. So far, the results about baPWV and CKD are not consistent. This study mainly discusses the relationship between baPWV and CKD. Methods 19 376 subjects who completed baPWV examination were analyzed, the average age was 50.5 years old. Among them, 12 533 men (64.8%) included estimated glomerular filtration rate (GFR) 60 mL/(min 路1.73 mm2) or urinary protein positive. Results the incidence of CKD increased with the increase of BaPWV3. In Logistic regression analysis, the age, sex and other mixed factors were adjusted. In the third position group, eGFR60mL/(min 路1.73 m-2, the OR value of urinary protein positive or CKD were 1.34 卤1.051.70 and 1.67 1.272.16 ~ 1.46 ~ 1.21 ~ 1.77, respectively. After the addition of a standard deviation of baPWV as an independent variable, many mixed factors were corrected. The odds ratio of eGFR60mL/(min 路1.73 m ~ (2) and urinary protein positive was 1.15 ~ 1.05 ~ (1.25) ~ 1.24 ~ 1.14 ~ 1.35 ~ 1.20 ~ 1.131.29 ~ 0.Conclusion the increase of baPWV is independently related to the occurrence of CKD. [WT5HZ] [WT5BZ] [WT5 "HZ] [WT5" BZ] [WT5BZ] the odds ratio of eGFR60mL/(min is 1.15?
【作者单位】：开滦林西医院心内科;华北理工大学研究生院;开滦总医院心内科;
【分类号】：R692

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