Gates法计算的GFR在单侧肾积水患者肾小球滤过功能评价中的应用

发布时间：2018-03-06 10:49

本文选题：肾积水　切入点：肾小球滤过率　出处：《山东医药》2016年37期 　论文类型：期刊论文

【摘要】：目的探讨Gates法计算的肾小球滤过率(GFR)对单侧肾积水患者肾小球滤过功能评估的价值。方法选择经B超检查确诊为单侧肾积水的患者176例(轻度积水组21例、中度积水组33例、重度积水组122例),同期选取泌尿系统及GFR均正常的肾移植供体捐献者22例(正常对照组)。两组均接受99mTc-DTPA肾动态显像检查,用Gates法计算患肾、健肾、双肾GFR值,根据单肾GFR将患者肾功能划分为肾功能正常、轻度下降、中度下降、重度下降及肾无功能。结果与正常对照组比较,中、重度积水组患侧肾GFR降低,轻、中、重度积水组健侧肾GFR升高,中、重度积水组双肾GFR降低(P均0.05)。轻度积水组90.48%的患肾GFR正常,中度积水组63.64%的患肾GFR轻度下降,重度积水组35.25%的患肾GFR重度下降、33.33%的患肾无功能。积水越严重肾功能越差。结论 Gates法计算的单肾、总肾GFR可定量分析单侧肾积水患者肾小球滤过功能,同步评价健侧肾的代偿能力。
[Abstract]:Objective to investigate the value of glomerular filtration rate (GFR) calculated by Gates method in evaluating glomerular filtration function in patients with unilateral hydronephrosis. Methods 176 patients with unilateral hydronephrosis (21 mild hydronephrosis and 33 moderate hydronephrosis) were selected. There were 122 patients with severe hydronephrosis and 22 donors with normal urinary system and GFR (normal control group). Both groups received 99mTc-DTPA renal dynamic imaging. The GFR values of affected kidney, healthy kidney and double kidney were calculated by Gates method. According to the single kidney GFR, the patients were divided into normal renal function, mild decline, moderate decline, severe decline and renal failure. Results compared with the normal control group, the patients with moderate and severe hydronephrosis had lower, mild and moderate renal GFR. In the severe hydronephrosis group, the GFR of the healthy kidney increased, while in the moderate and severe hydronephrosis group, the GFR of both kidneys decreased (P < 0.05). The GFR of the affected kidney in the mild hydronephrosis group (90.48%) was normal, while that in the moderate hydronephrosis group (63.64%) was slightly decreased. In severe hydronephrosis group (35.25%), GFR decreased significantly by 33.33%. The more severe hydronephrosis, the worse the renal function. Conclusion Gates method can quantitatively analyze glomerular filtration function in patients with unilateral hydronephrosis, and total renal GFR can be used to quantify glomerular filtration function in patients with unilateral hydronephrosis. The compensatory ability of healthy kidney was evaluated simultaneously.
【作者单位】：三峡大学第一临床医学院·宜昌市中心人民医院;南京大学医学院附属鼓楼医院;
【基金】：南京市医学科技发展项目(YKK13063)
【分类号】：R692.2

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