手术去势与药物去势治疗晚期前列腺癌的生活质量研究

发布时间：2018-03-09 03:06

本文选题：晚期前列腺癌　切入点：手术去势　出处：《兰州大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:回顾性分析手术去势与药物去势对晚期前列腺癌患者的生活质量的影响。方法:选取2014年1月—2016年3月在我院行去势治疗的125例患者作为研究对象,按其治疗方法的不同分为手术去势治疗组和药物去势治疗组,其中手术治疗组59例,药物治疗组66例。应用癌症患者生命质量测定量表(cancer quality of life questionnaire-30,QLQ-C30)及前列腺癌患者生活质量子量表(quality of life questionnaire of prostate cancer,QLQ-PR25)分别对治疗前、治疗后6个月、治疗后1年的患者生活质量进行评价。结果:与治疗前相比较,手术去势组与药物去势组患者总体健康状况均明显提高,排尿症状得到改善,疼痛症状得以缓解。手术去势组术后经济负担减轻,患者躯体功能、角色功能、社会功能、情绪功能均有所下降,疲乏症状加重,治疗相关症状如乳房胀痛、面色潮红等症状出现,性趣显著下降,性生活丧失。药物去势组在治疗后6个月患者经济负担加重,躯体功能、角色功能、社会功能、情绪功能有所下降,但在治疗1年后,患者经济负担减轻,角色、社会、情绪功能有所恢复,在治疗6个月后,患者出现的治疗相关症状,如乳房胀痛、面色潮红等明显加重,在治疗1年后可明显减轻。性趣、性生活在治疗6个月后明显降低甚至丧失,但在治疗1年后有一定程度的恢复。结论:两种去势方式均可对前列腺癌患者产生不同程度的影响,手术去势对患者的生活质量的影响是不可逆的,尤其是对性功能的影响,而药物去势对患者的部分生活质量的影响是可逆的。
[Abstract]:Objective: to retrospectively analyze the effect of surgical castration and drug castration on the quality of life of patients with advanced prostate cancer. Methods: 125 patients who were treated in our hospital from January 2014 to March 2016 were selected as study subjects. According to the different treatment methods, the patients were divided into two groups: the surgical castration group and the drug castration group, among which 59 cases were treated by the surgical treatment group. 66 patients in the drug treatment group were treated with quality of life questionnaire-30 QLQ-C30 and quality of life questionnaire of prostate cancer-QLQ-PR25 before and 6 months after treatment, respectively. Results: compared with those before treatment, the overall health status of patients in the castration group and the drug castration group were significantly improved, and the urination symptoms were improved. The pain symptoms were alleviated. In the castration group, the economic burden was reduced, the patients' somatic function, role function, social function, emotional function were decreased, the symptoms of fatigue were aggravated, and the treatment of related symptoms such as breast pain, Symptoms such as complexion flashes, sexual interest decreased significantly, sexual life was lost. Patients in the castration group had increased financial burden, body function, role function, social function and emotional function 6 months after treatment, but one year after treatment, the patients in the drug castration group had decreased financial burden, body function, role function, social function and emotional function, but after one year of treatment, After 6 months of treatment, the patients' symptoms, such as breast distension and facial redness, were obviously aggravated, and after one year's treatment, the patients' sexual interest could be significantly alleviated, and the patients' economic burden, role, social and emotional functions were somewhat improved, and after 6 months of treatment, the patients' symptoms, such as breast distension and flushing, were obviously aggravated. Sexual life was significantly decreased or even lost after 6 months of treatment, but recovered to a certain extent after one year of treatment. Conclusion: both castration methods have different effects on prostate cancer patients. The effect of surgical castration on the quality of life of patients is irreversible, especially on sexual function, while the effect of drug castration on part of quality of life is reversible.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.25

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