复方玄驹胶囊治疗少弱精子型男性不育症的临床研究

发布时间：2018-03-11 04:29

本文选题：少弱精子症　切入点：男性不育　出处：《兰州大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察复方玄驹胶囊治疗少弱精子型男性不育症的疗效。方法:由于目前临床上尚缺乏对少弱精子型男性不育症有确切疗效的药物,因此本研究采用观察服用复方玄驹胶囊的少弱精子型男性不育患者自身前后对照的方法进行临床研究。本方法的治疗周期为12周,每日给予44例入组的少弱精子型男性不育患者复方玄驹胶囊进行治疗。患者用药前、用药后6周及12周分别进行1次精液常规检查。研究开始后,每6周对入组患者随访一次,随访时严格记录患者的合并用药和不良事件发生情况,若有患者出现不良反应则及时向上级医师汇报,并进行相关处理。同时在研究期间详细记录患者配偶怀孕情况。同时在研究期间详细记录患者配偶怀孕情况。系统评价复方玄驹胶囊对少弱精子型男性不育患者的精液质量各项指标的改善情况,综合探讨其临床治疗效果。结果:本研究入组患者共44例,其中6例因失访或其他不符合研究要求最终未能完成研究,38例患者完成了研究,所有完成研究患者均严格按照上述研究方案及标准执行。与治疗前相比,在服用复方玄驹胶囊后,除精液量无显著性增加外(P0.05),其余精液参数如精子密度、a级精子、b级精子及(a+b)级精子比例及精子活动率在治疗6周和12周后均具有显著改善,差异具有统计学意义(P均0.05)。而且与服药6周后相比,服药12周后的精子密度、a级精子、b级精子及(a+b)级精子比例及精子活动率等各项精液参数也具有显著改善,差异有统计学意义(P均0.05)。与服药前相比服用复方玄驹胶囊治疗12周后,精子密度平均增加了83.24%,a级精子平均增加了69.02%,b级精子平均增加了73.83%,;(a+b)级精子提高了71.69%,精子活动率平均提高了45.41%。服用复方玄驹胶囊疗程结束后,患者总有效率为86.84%,痊愈8例,显效6例,有效19例,无效5例。结论:复方玄驹胶囊能够安全有效的提高少弱精子型男性不育患者的精子质量,提高男性的生育能力,未见明显不良反应。
[Abstract]:Objective: to observe the efficacy of compound Xuanju capsule in the treatment of male infertility with oligozoospermia. Therefore, the clinical study was carried out by observing the self-control method in patients with oligozoospermia male infertility taking compound Xuanju capsule. The treatment period of this method was 12 weeks. 44 patients with oligospermia male infertility were treated with Fufang Xuanju capsule daily. Routine semen examination was performed 6 weeks and 12 weeks after the treatment. The patients were followed up every 6 weeks after the beginning of the study. During the follow-up period, the patients' combined medication and adverse events were strictly recorded, and if any patients had adverse reactions, they were reported to their superior doctors in a timely manner. At the same time, the pregnancy of the spouse was recorded in detail during the study, and the pregnancy of the spouse was recorded in detail during the study. A systematic evaluation of Fufang Xuanju capsule for the treatment of oligozoospermic male infertility patients. To improve the quality of semen, Results: a total of 44 patients were included in the study, 6 of whom failed to complete the study because of lost visit or other noncompliance with the requirements of the study. All patients who completed the study were executed in strict accordance with the above study protocols and standards. Compared with before treatment, after taking compound Xuanju capsule, With the exception of no significant increase in the amount of spermatozoa, the other semen parameters, such as sperm density, sperm density, sperm density, sperm ratio and sperm motility rate, were significantly improved after 6 and 12 weeks of treatment. The difference was statistically significant (P < 0.05), and the sperm density, sperm density, sperm percentage and sperm motility were significantly improved after 12 weeks treatment. The difference was statistically significant (P < 0.05). After 12 weeks of treatment with compound Xuanju capsule, The average sperm density increased by 83.24a and increased by 69.02b. The average increase of sperm was 73.83 and 73.83. The sperm activity rate was increased by 45.41. The total effective rate of the patients was 86.84 after the treatment of Fuxianju capsule, and 8 cases were cured, and the average sperm density increased by 71.69 and 45.41.After the treatment of compound Xuanju capsule, the total effective rate of the patients was 86.84, and the recovery rate was 8 cases. Conclusion: compound Xuanju capsule can improve the sperm quality of infertile patients with oligozoospermia and improve male fertility without obvious adverse reactions.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R698.2

【相似文献】