中西医结合治疗去势抵抗性前列腺癌的疗效观察

发布时间：2018-03-12 14:12

本文选题：中西医结合　切入点：前列腺癌　出处：《中华男科学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的:探讨中西医结合治疗去势抵抗性前列腺癌(CRPC)的疗效。方法:54例CRPC患者随机均分为对照组和治疗组。对照组应用内分泌治疗(口服比卡鲁胺50 mg/d,每4周皮下注射戈舍瑞林3.6 mg)+化疗(每3周静脉滴注多西他赛75 mg/m2+口服泼尼松5 mg,早晚各1次),治疗组在其基础上加用扶阳化瘀方每日1剂,分早晚服,疗程均为24周。观察两组患者治疗前、治疗12及24周后血清前列腺特异抗原(PSA)水平、体力状况(Karnosky评分)、生活质量(FACT-P)及中医症状评分的变化。结果:治疗12周后,对照组与治疗组的血清PSA值分别由治疗前的(25.9±39.3)μg/L、(22.1±33.9)μg/L下降至(20.0±21.1)μg/L、(17.9±19.1)μg/L,两组较治疗前均有统计学差异(P0.05),两组间相比无统计学差异(P0.05)。治疗24周后,对照组与治疗组血清PSA较治疗3个月后分别小幅上升至(23.1±28.4)μg/L、(19.6±23.5)μg/L,但均无统计学差异(P0.05)。治疗组在治疗12周后体力状况、生活质量、中医症状评分均得到改善,较治疗前均有统计学差异(P0.05),治疗24周时较治疗12周时保持稳定;但对照组治疗12周、24周后体力状况、生活质量、中医症状评分均无明显改善(P0.05)。结论:扶阳益阴、解毒化瘀方联合化疗对CRPC具有一定的临床疗效,值得临床推广。
[Abstract]:Objective: to investigate the efficacy of combined Chinese and western medicine in the treatment of ovariectomized prostate cancer. Methods: 54 patients with CRPC were randomly divided into two groups: control group and treatment group. The control group was treated with endocrine therapy (oral Bi#internal_person0# amine 50 mg / d, subcutaneously every 4 weeks). The treatment group was treated with doxetaxel 75 mg/m2 oral prednisone 5 mg every 3 weeks. The treatment group was treated with Fuyang Huayu recipe once a day. The changes of serum prostate specific antigen (PSAs), physical status, Karnosky score, quality of life (QOL) and TCM symptom score were observed after 12 and 24 weeks of treatment in both groups. The serum PSA levels in the control group and the treatment group decreased from 25.9 卤39.3 渭 g / L to 20.0 卤21.1渭 g / L, respectively, from 25.9 卤39.3 渭 g / L before treatment to 17.9 卤19.1 渭 g / L before treatment. There was a significant difference between the two groups (P0.055.There was no significant difference between the two groups after 24 weeks of treatment. Serum PSA in control group and treatment group increased slightly to 23.1 卤28.4 渭 g / L, 19.6 卤23.5 渭 g / L, but there was no significant difference between control group and treatment group (P 0.05). After 12 weeks of treatment, the physical condition, quality of life and TCM symptom score in treatment group were improved. Compared with before treatment, there were statistical differences (P 0.05), and maintained stability at 24 weeks after treatment, but the physical condition, quality of life and TCM symptom score of control group were not significantly improved after 12 weeks of treatment and 24 weeks of treatment. Conclusion: Fuyang and Yin-nourishing, the control group has no significant improvement in physical condition, quality of life, and TCM symptom score after treatment for 12 weeks or 24 weeks. Jiedu Huayu recipe combined with chemotherapy has a certain clinical effect on CRPC, which is worth popularizing.
【作者单位】：南京中医药大学附属江苏省中医院泌尿外科;中国药科大学基础医学与临床药学学院;江苏省肿瘤医院普外科;南京中医药大学第一临床医学院中医内科学系;
【基金】：基金项目:江苏省中医药管理局(ZD201503)~~
【分类号】：R737.25

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