骨化三醇不同给药方式治疗维持性血液透析患者继发性甲状旁腺功能亢进的疗效观察

发布时间：2018-03-13 04:03

  本文选题：继发性甲状旁腺功能亢进　切入点：血液透析　出处：《安徽医科大学学报》2017年07期 　论文类型：期刊论文

【摘要】：探讨骨化三醇不同给药方式治疗维持性血液透析患者继发甲状旁腺功能亢进的疗效。选择医院血液净化中心血液透析合并继发性甲旁亢患者40例,分为静脉骨化三醇联合血液透析滤过组(治疗组)和口服骨化三醇联合血液透析滤过组(对照组)。依据全段甲状旁腺激素(iPTH)水平每组再分为2个亚组,治疗组1和对照组1(300 pg/ml≤iPTH≤600 pg/ml)、治疗组2和对照组2(iPTH600 pg/ml),疗程3个月。分别于治疗后1、2、3个月测定两组血清全段iPTH、碱性磷酸酶(AKP)、血钙、磷水平。3个月后,4组iPTH、AKP水平均较治疗前有了显著降低,差异有统计学意义(P0.05);与对照组1比较,治疗组1的AKP水平、iPTH水平差异无统计学意义;与对照组2比较,治疗组2的iPTH、AKP下降水平更为显著(P0.05)。静脉用骨化三醇能够有效降低iPTH水平,与口服用骨化三醇相比较疗效更为确切且较少引起高钙血症。
[Abstract]:To investigate the effect of different administration of ossifying triol on secondary hyperparathyroidism in patients with maintenance hemodialysis, 40 cases of hemodialysis complicated with secondary hyperthyroidism in blood purification center of hospital were selected. They were divided into intravenous ossifying triol combined hemodiafiltration group (treatment group) and oral ossifying triol combined hemodiafiltration group (control group). Treatment group 1 and control group 1: 300 pg/ml 鈮，

本文编号：1604698