前列腺腺癌中整合素αvβ3、基质金属蛋白酶-2和-9表达及关系

发布时间：2018-03-13 14:32

本文选题：前列腺腺癌　切入点：整合素αvβ　出处：《中国老年学杂志》2017年20期 　论文类型：期刊论文

【摘要】：目的检测前列腺腺癌中整合素αvβ3、基质金属蛋白酶(MMP)-2和-9表达,分析其相关性及在不同临床病理特征中的意义。方法观察组为58例前列腺腺癌患者,对照组为31例前列腺增生患者,均留取术后新鲜组织,两组中整合素αvβ3、MMP-2和MMP-9表达应用流式细胞术检测。结果整合素αvβ3、MMP-2和MMP-9在观察组中表达量明显高于对照组。观察组中整合素αvβ3、MMP-2和MMP-9表达量均与增殖指数、Gleason评分和转移相关。观察组中整合素αvβ3和MMP-2、整合素αvβ3和MMP-9的表达呈正相关。结论前列腺腺癌中存在着明显的整合素αvβ3、MMP-2和MMP-9的高表达,三种蛋白在肿瘤发生中可能有一定促进作用。整合素αvβ3可能通过对细胞外基质进行降解促进肿瘤进展。
[Abstract]:Objective to detect prostate cancer in integrin alpha v beta 3, matrix metalloproteinase (MMP) -2 and -9 expression, to analyze the correlation and significance in different clinical and pathological features. Methods in the observation group of 58 cases of prostate cancer patients, the control group for 31 cases of benign prostatic hyperplasia patients were left fresh tissue after operation. The two group of integrin alpha v beta 3, MMP-2 and MMP-9 expression was detected by flow cytometry. Results the expression of integrin alpha v beta 3, MMP-2 and MMP-9 in the observation group were significantly higher than the control group. The observation group of integrin alpha v beta 3, MMP-2 and MMP-9 expression and proliferation index, Gleason score and transfer in the observation group. Integrin alpha v beta 3 and MMP-2. The expression of integrin alpha v beta 3 and MMP-9. Conclusion the prostate cancer has obvious integrin alpha v beta 3, high expression of MMP-2 and MMP-9, three kinds of protein may have a role in the tumorigenesis of integrin alpha. V beta 3 It may be possible to degrade the extracellular matrix to advance the progression of the tumor.

【作者单位】：青海红十字医院泌尿外科;
【分类号】：R737.25

【相似文献】