前列腺介入手术穿刺力学建模及误差分析

发布时间：2018-03-13 14:49

本文选题：穿刺介入手术　切入点：变形模型　出处：《天津大学》2014年硕士论文　论文类型：学位论文

【摘要】：本文研究了穿刺治疗手术中影响放射性粒子植入精度的两大主要因素—柔性针变形和软组织变形。并结合具有相同人体解剖结构的盆腔器官群模型,深入探讨了前列腺穿刺过程中柔性针与软组织力学交互机理和靶点误差变化规律。研究结果有助于正确认识穿刺粒子植入手术过程中误差的产生机理与补偿方法,可以应用于术前轨迹规划、剂量规划、手术模拟训练等领域。主要内容如下所述:首先,根据针刺力实验,建立了柔性针变形模型。重点研究了柔性针与软组织的交互作用,并对柔性针和软组织相关参数进行参数化分析。通过针穿刺实验与模型敏感度分析,分析并验证了针变形模型在不同参量影响下的有效性。其次,以柔性针变形为输入量,采用有限元方法,研究了穿刺过程中的软组织变形。根据柔性针与软组织的力学交互,得到了目标点位置的偏移量。结合解剖学知识和三维重建技术将变形模拟扩展到三维器官群,计算出总体穿刺误差。最终通过实验进行误差补偿最后,根据重建器官的空间位置及外形尺寸参数,制作人造器官群模具,参考各器官与组织在人体中的实际约束关系,对具有自主知识产权的水凝胶软组织器官群进行装配。分别搭建了力学和变形实验平台,进行器官群针刺力学实验与误差验证实验。
[Abstract]:In this paper, two main factors that affect the precision of radioactive particle implantation in puncture treatment are studied, which are flexible needle deformation and soft tissue deformation, and combined with pelvic organ swarm model with the same anatomical structure of human body. The interaction mechanism of flexible needle and soft tissue mechanics and the variation of target error in the process of prostate puncture are discussed in depth. The results are helpful to correctly understand the mechanism and compensation method of errors in the process of puncture particle implantation. It can be used in the fields of preoperative trajectory planning, dose planning, surgical simulation training and so on. The main contents are as follows: firstly, according to the acupuncture force experiment, a flexible needle deformation model is established, and the interaction between flexible needle and soft tissue is mainly studied. Through the needle puncture experiment and the sensitivity analysis of the model, the validity of the needle deformation model under the influence of different parameters is analyzed and verified. Secondly, the flexible needle deformation is taken as the input quantity. The soft tissue deformation during puncture was studied by finite element method. According to the mechanical interaction between flexible needle and soft tissue, The displacement of the target point is obtained. Combined with anatomical knowledge and 3D reconstruction technique, the deformation simulation is extended to the three-dimensional organ group, and the total puncture error is calculated. Finally, the error compensation is carried out through experiments. According to the parameters of space position and shape size of reconstructed organs, the mould of artificial organ group is made, and the actual constraint relation between organs and tissues in human body is referred to. The hydrogel soft tissue organ group with independent intellectual property rights was assembled, and the mechanical and deformation experiment platforms were set up, and the acupuncture mechanics experiment and error verification experiment of organ group were carried out.
【学位授予单位】：天津大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.25

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