前列腺癌诊断中核磁弥散成像及ADC值的应用价值

发布时间：2018-03-15 05:40

本文选题：前列腺癌　切入点：前列腺增生　出处：《临床泌尿外科杂志》2015年09期 　论文类型：期刊论文

【摘要】：目的:探讨核磁共振弥散加权成像(DWI)及表观弥撒系数(ADC)在前列腺癌诊断中的应用价值。方法:回顾性分析我院自2009年1月~2013年12月95例行DWI检查后经穿刺活检或外科手术证实为前列腺癌或BPH患者的临床及影像学资料,分别对不同b值下前列腺癌与BPH组织ADC值进行比较,并分析前列腺癌ADC值与肿瘤Gleason评分、ADC值与血清前列腺特异性抗原(PSA)之间的相关性。结果:95例患者中,b为600s/mm2时,前列腺癌与BPH患者中央腺体的平均ADC值分别为(1.31±0.35)×10-3 mm2/s和(1.55±0.17)×10-3 mm2/s,外周带平均ADC值为(1.20±0.38)×10-3 mm2/s和(1.42±0.23)×10-3 mm2/s;b为1 000s/mm2时,前列腺癌与BPH患者中央腺体的平均ADC值分别为(1.12±0.36)×10-3 mm2/s和(1.39±0.16)×10-3 mm2/s,外周带平均ADC值为(1.04±0.35)×10-3 mm2/s和(1.25±0.19)×10-3 mm2/s。当b为1 000s/mm2时,前列腺癌ADC值与其Gleason评分有相关性,为负相关(r=-0.346,P=0.025);还与血清PSA水平有相关性,为负相关(r=-0.315,P=0.026)。结论:ADC值是区别患者前列腺癌和BPH的重要指标,并且可以预测前列腺癌的生物学特性。
[Abstract]:Objective: to evaluate the value of diffusion weighted imaging (DWI) and apparent mass coefficient (DWI) in the diagnosis of prostate cancer. Methods: from January 2009 to December 2013, 95 cases of DWI in our hospital were examined by biopsy or biopsy. Clinical and imaging data of patients with prostate cancer or BPH confirmed by surgery, The ADC values of prostate cancer and BPH tissue were compared under different b values, and the correlation between ADC value and Gleason score of prostate cancer and serum prostate specific antigen (PSA) was analyzed. The mean ADC values of central glands in prostate cancer and BPH patients were 1.31 卤0.35 脳 10 -3 mm2/s and 1.55 卤0.17 脳 10 -3 mm 2 / s, respectively. The mean ADC value of peripheral zone was 1.20 卤0.38 脳 10 -3 mm2/s and 1.42 卤0.23 脳 10 -3 mm 2 / s 2 respectively. The mean ADC values of central glands of prostate cancer and BPH were 1.12 卤0.36 脳 10 -3 mm2/s and 1.39 卤0.16) 脳 10 -3 mm 2 / s, respectively. The mean ADC values of peripheral zone were 1.04 卤0.35 脳 10 -3 mm2/s and 1.25 卤0.19 脳 10 -3 mm 2 / s respectively. There was also a negative correlation between the serum PSA level and the serum PSA level. Conclusion the ratio of 0: ADCs is an important index to distinguish prostate cancer from BPH, and the biological characteristics of prostate cancer can be predicted.
【作者单位】：新疆维吾尔自治区人民医院泌尿中心二科;
【分类号】：R737.25

【共引文献】