慢性肾脏病各期唾液酸、同型半胱氨酸及胱抑素C水平的变化及其临床意义

发布时间：2018-03-15 07:39

本文选题：胱抑素C　切入点：同型半胱氨酸　出处：《东南大学学报(医学版)》2016年04期 　论文类型：期刊论文

【摘要】：目的:探讨慢性肾脏病(CKD)各期胱抑素C(Cys C)、同型半胱氨酸(Hcy)、唾液酸(SA)的水平变化。方法:选择CKD病人129例(CKD 1期31例,2期18例,3期17例,4期12例,5期51例)作为研究组,同期健康体检者32例作为对照组,收集研究对象Cys C、Hcy、SA数据进行统计分析。结果:CKD各期Hcy、Cys C、SA逐渐升高,与对照组间差异均有统计学意义。其中Cys C在CKD各期间差异均有统计学意义;Hcy在CKD 5期与1、2、3期间差异具有统计学意义,2、3、4期间差异无统计学意义,1期与2、3、4、5期间差异均有统计学意义;SA在CKD 5期与1、2、3、4期间差异均有统计学意义;Spearman相关性分析显示,Hcy、SA、Cys C与e GFR均呈负相关(r=-0.606,P=0.000;r=-0.571,P=0.000;r=-0.911,P=0.000);Logistic回归分析显示,以e GFR为因变量,Cys C(OR=29.816,95%CI为7.490~118.69,P=0.000)和Hcy(OR=1.107,95%CI为1.024~1.198,P=0.011)具有统计学意义。结论:Cys C与Hcy是CKD开始恶化的独立危险因素;SA对CKD进展到终末期的判定具有临床意义。
[Abstract]:Objective: to investigate the changes of cystatin Cys Con, homocysteine cystatin and sialic acid in all stages of chronic kidney disease (CKD). Methods: one hundred and twenty-nine patients with CKD, including 18 patients with stage 1, 18 patients with stage 3, 12 patients with stage 4 and 51 patients with stage 5, were selected as the study group. In the same period, 32 healthy persons were taken as the control group. The data of Cys cystatin SA were collected and analyzed. The difference between Cys C and control group was statistically significant. The difference of Cys C in each period of CKD was statistically significant. There were statistically significant differences in SA between stage 5 and stage 1 of CKD. The results of Spearman correlation analysis showed that there was a negative correlation between CKD C and e GFR. Logistic regression analysis showed that there was a negative correlation between Hcystoma C and e GFR in the period of CKD 5 and 1: 0. 571P0. 000r-0.911P0. 000and logistic regression analysis showed that there was a negative correlation between SASs C and e GFR. With e GFR as dependent variable, CI was 7.490 and 1.10795 CI, respectively. Conclusion GFR C and Hcy are independent risk factors for the beginning and deterioration of CKD. Conclusion SA has clinical significance in judging the progression of CKD to the end stage.
【作者单位】：安徽医科大学第一附属医院检验科;铜陵市立医院检验科;
【分类号】：R692

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