前列腺抗原和骨标志物在老年前列腺癌骨转移患者中的表达及意义

发布时间：2018-03-16 15:47

本文选题：前列腺癌　切入点：骨转移　出处：《中国老年学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨前列腺特异性抗原(PSA)、Ⅰ型胶原羧基末端肽(CTx)、骨钙素(OST)和骨特异性碱性磷酸酶(BAP)在前列腺癌及骨转移患者中的意义。方法通过采用放射免疫法和酶联免疫分析法测定90例老年前列腺癌患者,其中骨转移58例;进展性骨转移20例和局限性骨转移38例。血清中PSA、CTx、OST、BAP的浓度变化,受试者工作特征曲线(ROC)评估各标志物在前列腺癌骨转移的价值。结果骨转移组血清PSA、CTx、OST、BAP浓度均高于无骨转移组(P0.05);与局限性骨转移组比较,PSA、CTx、OST、BAP浓度在进展性骨转移组中均有明显升高(P0.05);ROC诊断前列腺癌骨转移标志物PSA、CTx、BAP、OST的曲线下面积(AUC)分别为0.795、0.656、0.752、0.733,其敏感性及特异性分别为66.8%、59.2%、37.1%、58.3%;90.0%、80.0%、96.6%、76.5%;PSA、CTx、OST、BAP是可预测前列腺癌骨转移的独立性因素,其总符合率为84.3%。结论PSA、CTx、OST、BAP水平在前列腺癌骨转移患者中明显升高,联合检测有可能在前列腺癌骨转移早期诊断中有重要价值。
[Abstract]:Objective to investigate the significance of prostate specific antigen (PSAA), type I collagen carboxyl terminal peptide (CTX), osteocalcin (OST) and bone specific alkaline phosphatase (BAP) in patients with prostate cancer and bone metastasis. Methods Radioimmunoassay and enzyme-linked immunosorbent assay (Elisa) were used. 90 elderly patients with prostate cancer were measured by analytical method. There were 58 cases of bone metastasis, 20 cases of progressive bone metastasis and 38 cases of localized bone metastasis. Results the serum concentration of PSACTxX OSTP BAP in bone metastasis group was higher than that in non-bone metastasis group (P 0.05), and the BAP concentration in bone metastasis group was higher than that in bone metastases group (P < 0.05), and the BAP level in bone metastasis group was higher than that in bone metastases group (P < 0.05), and the BAP level in bone metastases group was higher than that in bone metastases group (P < 0.05). The area under the curve of PSA-CTX BAP-OST was 0.795U 0.656U 0.7520.333.The sensitivity and specificity of ROC in diagnosis of prostate cancer bone metastases were 66.8 / 59.2ng58.30.080.080.080.080.080.080.080.080.086.676. 5 and 76. 5% respectively. The OSTBAP was an independent factor in predicting bone metastases of prostate cancer, and AUC was a valuable predictor of bone metastasis of prostate cancer, and the sensitivity and specificity of ROC in diagnosis of bone metastasis of prostate cancer were 96. 6% and 76. 5%, respectively, and the sensitivity and specificity of ROC in diagnosing bone metastasis of prostate cancer were 96. 6% and 76. 5% respectively. Conclusion the level of BAP in bone metastases of prostate cancer is significantly higher than that of the control group, and the combined detection may be of great value in the early diagnosis of bone metastasis of prostate cancer.
【作者单位】：青州市人民医院泌尿外科;
【分类号】：R737.25

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