去势抵抗性前列腺癌患者冷冻消融治疗后中性粒细胞与淋巴细胞比值变化的意义

发布时间：2018-03-17 22:18

本文选题：去势抵抗性前列腺癌　切入点：中性粒细胞/淋巴细胞比值　出处：《介入放射学杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨去势抵抗性前列腺癌(CRPC)患者氩氦冷冻消融术前外周血中性粒细胞与淋巴细胞比值(NLR)变化的意义。方法收集并分析天津医科大学肿瘤医院33例行氩氦冷冻消融术的CRPC患者的临床病理资料。将可能影响术后总生存期(OS)的因素:年龄、基线前列腺特异抗原(PSA)水平、血红蛋白、白细胞计数、血小板计数、白蛋白、碱性磷酸酶、NLR、血小板与淋巴细胞比值(PLR)、激素敏感时间、是否化疗、有无骨转移、Gleason评分、ECOG评分、PSA有效率进行单因素和多因素分析。结果本研究共33例患者,平均年龄为69岁(50~82岁),中位生存期为28个月(6~55个月),单因素分析显示:基线PSA水平、碱性磷酸酶、NLR、激素敏感时间、是否化疗、有无骨转移、Gleason评分、PSA有效率是影响CRPC患者冷冻消融术后OS的相关因素(P0.05)。多因素分析显示:基线PSA水平(P=0.003)、NLR(P=0.009)、Gleason评分(P0.001)是CRPC患者冷冻消融术后OS的独立预测因子。结论 NLR可作为CRPC患者行氩氦冷冻消融术的预后指标,NLR升高提示患者预后不良。
[Abstract]:Objective to investigate the significance of the changes of the ratio of neutrophils to lymphocytes in peripheral blood before argon helium cryopreservation in patients with castrated and resistant prostate cancer (CRPC). Methods 33 cases of Argon-helium cryopreservation in Tianjin Medical University Cancer Hospital were collected and analyzed. Clinicopathological data of CRPC patients undergoing ablation. Factors that may affect the overall survival time after operation: age, Baseline prostate specific antigen (PSA) level, hemoglobin, leukocyte count, platelet count, albumin, alkaline phosphatase (ALP) NLR, platelet to lymphocyte ratio (PLR), hormone sensitive time, whether chemotherapy, The effective rate of Gleason score and ECOG score was analyzed by univariate and multivariate analysis. Results the mean age of 33 patients was 69 years old and 82 years old, and the median survival time was 28 months or 65 months. Univariate analysis showed that the baseline PSA level. Alkaline phosphatase NLR, hormone sensitive time, whether chemotherapy, The effective rate of Gleason score (Gleason score) was the independent predictor of postoperative OS in patients with CRPC after cryopreservation. Multivariate analysis showed that baseline PSA level was 0.003 / 0. 009 and Gleason score P0.001 was an independent predictor of OS after cryopreservation in CRPC patients. NLR may be used as a prognostic index of argon helium cryopreservation in CRPC patients.
【作者单位】：天津医科大学肿瘤医院介入治疗科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室;
【分类号】：R737.25

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