137例前列腺增生患者接受非那雄胺治疗不同时段的疗效

发布时间：2018-03-18 03:27

本文选题：非那雄胺　切入点：前列腺增生　出处：《中国老年学杂志》2016年07期 　论文类型：期刊论文

【摘要】：目的观察长期接受非那雄胺(保列治)治疗前列腺增生的有效性和安全性。方法选取治疗并长期随访的离退休干部137例,每日服用保列治5 mg并长期治疗超过3年的前列腺增生患者84例,与患有前列腺增生,旦未服用保列治的患者53例,定期观察血清前列腺特异性抗原(PSA)浓度、B超测定前列腺体积,定期发放问卷统计患者自主症状变化情况。结果在实验开始后3个月的观察点,治疗组的血清PSA与前列腺体积均较基线有显著下降(P0.05),而未治组的两项指标与基线相比无明显变化。两组的前列腺体积变化程度相比有显著差异(P0.05),而PSA浓度变化无明显差异。在6个月及以后的各观察点,这两项指标在两组间比较均有显著差异(P0.05),而未治组前列腺体积持续增长,在组内与基线两两比较有统计学差异(P0.05),未治组血清PSA浓度在各观察点无明显变化。主观症状方面,治疗组自诉主观症状改善的患者比例持续增加,而未治组自诉主观症状加重的比例不断增加。结论长期服用保列治可有效改善前列腺增生患者的主观症状,可有效减小前列腺体积,改善由于前列腺增生带来的尿路梗阻症状,用于老年患者时,药物安全性较好。
[Abstract]:Objective to observe the efficacy and safety of fenasteride in the treatment of benign prostatic hyperplasia (BPH). Eighty-four patients with benign prostatic hyperplasia (BPH) who had been treated with 5 mg per day for more than 3 years were compared with 53 patients who had BPH and were not treated with BPH. The concentration of serum prostate specific antigen (PSAA) was observed regularly, the volume of prostate was measured by B-ultrasound, and the changes of patients' autonomic symptoms were measured by regular questionnaires. The serum PSA and prostate volume in the treatment group were significantly lower than those in the baseline group, while the two indexes in the untreated group had no significant change compared with the baseline. There was a significant difference in the change of prostate volume between the two groups (P 0.05), but there was no change in the concentration of PSA in the two groups. Significant differences. At and after 6 months of observation, There were significant differences between the two groups in the two groups, but the volume of prostate in the untreated group increased continuously, and there was a significant difference between the two groups in comparison with the baseline (P 0.05). There was no significant change in serum PSA concentration in the untreated group at all observation points, but in subjective symptoms, there was no significant difference between the two groups. In the treatment group, the proportion of the patients with the subjective symptoms of private complaint increased continuously, while that of the non-treated group increased. Conclusion taking Baoli for a long period of time can effectively improve the subjective symptoms of the patients with benign prostatic hyperplasia (BPH). It can effectively reduce the volume of prostate and improve the symptoms of urinary tract obstruction caused by prostatic hyperplasia.
【作者单位】：成都军区总医院干部病房四病区;
【分类号】：R697.3

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