赛洛多辛对大鼠慢性细菌性前列腺炎组织中左氧氟沙星药动学的影响

发布时间：2018-03-19 08:47

本文选题：赛洛多辛　切入点：左氧氟沙星　出处：《重庆医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的：研究赛洛多辛对左氧氟沙星在慢性细菌性前列腺炎(CBP)大鼠前列腺组织中药动学的影响。方法：构建SD大鼠慢性细菌性前列腺炎模型96只,并随机分成对照组(单用左氧氟沙星)和实验组(赛洛多辛和左氧氟沙星联合用药),每组各48只,分别于给药后0.125、0.25、0.5、1、2、4、8和12 h每个时间点处死6只模型大鼠,采集两组大鼠的前列腺制作前列腺组织匀浆,高效液相色谱(HPLC)测定组织中左氧氟沙星浓度,使用3p97软件计算相关药动学参数。结果：对照组和实验组的药-时曲线均符合一室模型。计算出的药动学参数如下：t1/2分别为(4.34±0.25)h和(5.02±0.28)h,tpeak分别为(0.73±0.20)h和(0.86±0.05)h,CL分别为(1.74±0.19)mg/h和(0.64±0.06)mg/h,Cmax分别(3.62±0.3)mg/kg和(8.47±0.51)mg/kg, AUC0-12分别为(21.58±2.00) mg·h/kg和(56.63±4.30) mg·h/kgo实验组与对照组比较,两组在t1/2上的差异有统计学意义(P0.05)；两组在CL,Cmax,AUC0-12上的差异有显著统计学意义(P0.01)；而两组在tpeak比较上,差异无统计学意义(P0.05)。结论：赛洛多辛能明显提高慢性细菌性前列腺炎模型大鼠前列腺组织中左氧氟沙星的药物浓度。
[Abstract]:Objective: to study the effect of sellodoxin on prostatic tissue of rats with levofloxacin in chronic bacterial prostatitis (CBP) rats. Methods: 96 SD rats with chronic bacterial prostatitis were established. They were randomly divided into two groups: the control group (levofloxacin alone) and the experimental group (sellodoxin combined with levofloxacin), 48 rats in each group, and 6 model rats were killed at each time point of 0.125 and 0.25 and 12 hours, respectively. The prostate tissue homogenate of two groups of rats was collected and the concentration of levofloxacin was determined by high performance liquid chromatography (HPLC). The pharmacokinetic parameters were calculated by 3p97 software. Results: the pharmacokinetic parameters of the control group and the experimental group were in accordance with the one-compartment model. The pharmacokinetic parameters calculated were as follows: t 1 / 2 = 4.34 卤0.25 h and 5.02 卤0.28 h / h respectively: 0.73 卤0.20 h and 0.86 卤0.05 h, respectively, and the pharmacokinetic parameters were 1.74 卤0.19 mg / h and 0.64 卤0.06 mg / h, respectively. Compared with the control group, the AUC0-12 of the experimental group was 21.58 卤2.00 mg 路h / kg and 56.63 卤4.30 mg 路h / kg, respectively, and that of the control group was 8.47 卤0.51 mg 路kg 路kg 路h / kg, 3.62 卤0.3 mg / kg and 8.47 卤0.51g / kg, respectively. The difference in t1 / 2 between the two groups was statistically significant (P0.05A), the difference between the two groups in the CmaxCmaxAUC 0-12 was statistically significant (P0.01A), and the difference between the two groups in tpeak was significantly higher than that in the control group (P < 0.05), but the difference between the two groups was significant (P < 0.05). Conclusion: the concentration of levofloxacin in prostatic tissue of rats with chronic bacterial prostatitis can be increased obviously.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R697.33

【相似文献】