膀胱癌组织Caveolin-1表达与膀胱癌病理分级和临床分期相关性的Meta分析

发布时间：2018-03-22 23:42

本文选题：膀胱癌　切入点：小窝蛋白　出处：《山东医药》2017年40期 　论文类型：期刊论文

【摘要】：目的探讨膀胱癌组织小窝蛋白1(Caveolin-1)表达与膀胱癌病理分级和临床分期的相关性。方法检索Pub Med、EMBASE、Cochrane Library、CNKI万方数据库,按照纳入和排除标准选择研究膀胱癌组织Caveolin-1表达与膀胱癌病理分级和临床分期的相关性文献,评价纳入文献质量并提取资料。将各文献中的资料合并,比较合并后的高、低病理分级膀胱癌患者和浅表型、浸润型膀胱癌患者膀胱癌组织Caveolin-1阳性表达率。结果共10篇文献纳入本研究,共501例患者。10篇文献均涉及膀胱癌组织Caveolin-1表达与膀胱癌病理分级相关性,其中高、低病理分级患者膀胱癌组织Caveolin-1阳性表达率分别为60.1%±16.0%、18.1%±9.0%,高、低病理分级者膀胱癌组织Caveolin-1阳性表达率比较P0.05。癌组织中Caveolin-1表达与膀胱癌病理分级有关,合并OR值为0.14,95%CI为0.08~0.23,P0.05。8篇文献涉及膀胱癌组织Caveolin-1表达与膀胱癌临床分期相关性,其中表浅型、浸润型膀胱癌组中Caveolin-1阳性表达率分别为20.2%±13.9%、55.8%±14.3%,表浅型、浸润型膀胱癌组中Caveolin-1阳性表达率相比P0.05。膀胱癌组织Caveolin-1表达与膀胱癌临床分期有关,合并OR值为0.15,95%CI为0.10~0.23,P0.05。结论膀胱癌组织中Caveolin-1表达与膀胱癌病理分级、临床分期有关。
[Abstract]:Objective to investigate the caveolin 1 bladder cancer tissue (Caveolin-1) expression of bladder cancer staging and pathological grading and clinical. Methods we searched the Pub Med, EMBASE, Cochrane, Library, CNKI, Wanfang database, according to the inclusion and exclusion criteria selection of bladder cancer and Caveolin-1 expression in bladder cancer staging and pathological grading and clinical relevance of literature evaluation the quality of the included studies and extracted data. The literatures with comparison after the merger of high and low grade bladder cancer and pathology in patients with superficial bladder cancer patients, invasive bladder cancer tissues the positive expression rate of Caveolin-1. Results: a total of 10 articles were included in the study, a total of 501 cases of patients with bladder cancer were related to.10 documents the expression of Caveolin-1 and bladder cancer pathological correlation, which is high, low pathological grade of patients with bladder cancer tissues the positive expression rate of Caveolin-1 was 60.1% + 16%, 18.1% + 9%, high, Low pathological grade Caveolin-1 positive rate of bladder cancer and bladder cancer pathological grade on Caveolin-1 expression of P0.05. in cancer tissues, with OR value of 0.14,95%CI is 0.08~0.23, P0.05.8 articles related to bladder cancer Caveolin-1 expression and clinical staging of bladder cancer related, including superficial bladder cancer invasion, Caveolin-1 positive expression group rates were 20.2% + 13.9%, 55.8% + 14.3%, superficial type, infiltration type Caveolin-1 bladder cancer group the positive expression rate of P0.05. in bladder cancer tissue Caveolin-1 expression associated with clinical staging of bladder cancer, with OR value of 0.15,95%CI is 0.10~0.23, and bladder cancer pathological grading Caveolin-1 conclusion the expression of P0.05. in bladder cancer, clinical staging.

【作者单位】：广西医科大学第一附属医院;
【分类号】：R737.14

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