环磷酰胺与来氟米特联合小剂量糖皮质激素治疗狼疮性肾炎患者的疗效

发布时间：2018-03-27 15:00

本文选题：环磷酰胺　切入点：来氟米特　出处：《中国老年学杂志》2017年10期

【摘要】：目的探讨环磷酰胺(CTX)与来氟米特(LEF)联合小剂量糖皮质激素(GC)治疗狼疮性肾炎(LN)患者的临床疗效。方法 105例LN患者随机分为对照A组(GC联合CTX)、对照B组(GC联合LEF)和三联组(GC、CTX联合LEF3)各35例,均治疗12个月。评价并比较3组临床疗效及不良反应发生率,检测3组治疗前后尿蛋白、尿红细胞、血浆白蛋白、血清肌酐清除率(Scr)及红细胞沉降率(ESR)水平。结果三联组总有效率明显高于对照A组和对照B组(P0.05)。治疗后,3组尿蛋白、尿红细胞、Scr、ESR水平均明显低于治疗前,血浆白蛋白水平明显高于治疗前,且三联组以上各检测指标水平变化均明显优于对照A组和对照B组(P0.05)。治疗过程中,3组不良反应总发生率无统计学差异(P0.05)。结论CTX与LEF联合小剂量GC治疗LN的临床疗效显著,能够明显改善各项生化指标,且安全性较好。
[Abstract]:Objective to investigate the clinical effect of cyclophosphamide (CTX) and leflunomide (leflunomide) combined with low dose glucocorticoid (GCC) in the treatment of lupus nephritis (LN). There were 35 cases of GCU CTX combined with LEF3 in the triple group, 35 cases in each group. All patients were treated for 12 months. The clinical efficacy and incidence of adverse reactions were evaluated and compared. Urine protein, urine erythrocyte and plasma albumin were detected before and after treatment. Results the total effective rate of the triple group was significantly higher than that of the control group A and B group (P 0.05). After treatment, the levels of urinary protein and erythrocyte crin ESR in the three groups were significantly lower than those before treatment. The plasma albumin level was significantly higher than that before treatment. The changes of the above indexes in the triple group were significantly better than those in the control group A and group B. there was no significant difference in the total incidence of adverse reactions among the three groups during the treatment. Conclusion the clinical efficacy of CTX and LEF combined with low-dose GC in the treatment of LN is significant. Can obviously improve each biochemical index, and the safety is good.
【作者单位】：遵义市第一人民医院免疫肾病科;
【分类号】：R593.242

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