雌激素受体α基因rs2234693位点多态性与前列腺癌易感性的meta分析

发布时间：2018-03-28 00:06

本文选题：雌激素受体α　切入点：基因多态性　出处：《中国病理生理杂志》2015年01期

【摘要】：目的:探讨雌激素受体α(ESRα)基因rs2234693位点多态性与前列腺癌易感性的关系。方法:通过计算机检索Pub Med、CNKI和万方数据库,根据纳入与排除标准筛选相关的病例对照研究,检索时限至2014年4月。在提取有效资料后,应用Stata 10.1分析软件对各项研究进行异质性检验,在随机效应模型下计算合并优势比及其95%可信区间。结果:该Meta分析共纳入20项研究,累计前列腺癌组4 623例,对照组9 850例。ESRαrs2234693位点多态性在总体人群中与前列腺癌易感性明显相关(P0.05),通过种族的亚组分析发现ESRαrs2234693位点多态性与前列腺癌易感性在欧洲人群中具有相关性(P0.05),然而在亚洲和非洲人群中无明显关联性(均P0.05)。结论:ESRα基因rs2234693位点态性与前列腺癌易感性相关,即rs2234693的CC基因型可增加人群患前列腺癌的风险,尤其是欧洲人群。
[Abstract]:Objective: to investigate the relationship between the rs2234693 polymorphism of estrogen receptor 伪 ESR 伪) gene and the susceptibility to prostate cancer. The retrieval time was up to April 2014. After the valid data were extracted, the heterogeneity of each study was tested by using Stata 10.1 analysis software. The combined odds ratio and its 95% confidence interval were calculated under the stochastic effect model. Results: the Meta analysis included 20 studies, with a total of 4623 prostate cancer patients. The polymorphism of ESR 伪 rs2234693 locus was significantly associated with the susceptibility to prostate cancer in the population in the control group (9 850 cases). The ethnic subgroup analysis showed that the polymorphism of the ESR 伪 rs2234693 locus was associated with the susceptibility to prostate cancer in the European population. However, the polymorphism of the ESR 伪 rs2234693 locus was associated with the susceptibility to prostate cancer in the European population. There was no significant association between Asian and African populations (P0.05). Conclusion the rs2234693 loci of the ESR 伪 gene are associated with the susceptibility to prostate cancer. The CC genotype of rs2234693 increases the risk of prostate cancer, especially in Europe.
【作者单位】：中山大学附属第五医院介入科;中山大学附属第五医院心内科;中山大学附属第五医院冠心病重症监护室;
【基金】：珠海市科技计划项目(No.2012D0401990002)
【分类号】：R737.25

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