黑种草子油改善药物性肾损害作用机制的研究进展

发布时间：2018-03-28 02:37

  本文选题：黑种草子油　切入点：药物性肾损害　出处：《中国医院药学杂志》2017年19期

【摘要】：黑种草(Nigella),属毛茛科,为一年生草本植物,原产于地中海地区和北非,我国新疆、西藏和云南也有种植。作为药用的黑种草主要有3种,分别是瘤果黑种草(Nigella glandulifera)、果黑种草(Nigella sativa)和黑种草(Nigella damascena)。黑种草的种子(以下简称"黑种草子")含有多种成分,包括生物碱、皂苷、不饱和脂肪酸、挥发油等,具有抗氧化、抗炎等药理作用。黑种草子很早就被用于多种疾病的治疗,如哮喘、头痛、糖尿病等。近几年发现黑种草子油通过减少药物蓄积、抗氧化、抗炎、抗凋亡和抗纤维化对药物性肾损害也有改善作用。笔者对近年来有关黑种草子油改善药物性肾损害的作用机制做一综述,为进一步的开发利用提供参考。
[Abstract]:Nigellaus, a family of Ranunculaceae, is an annual herbaceous plant native to the Mediterranean and North Africa, and is also cultivated in Xinjiang, Tibet and Yunnan in China. They are Nigella glandulifera, Nigella sativa and Nigella damascena, respectively. The seeds recommended by black (hereinafter referred to as "black seed grass") contain many components, including alkaloids, saponins, unsaturated fatty acids, volatile oils and so on. Antiinflammatory and other pharmacological effects. Black grass has long been used in the treatment of many diseases, such as asthma, headache, diabetes and so on. In recent years, it has been found that black grass oil reduces drug accumulation, antioxidant, anti-inflammation, etc. Anti-apoptosis and anti-fibrosis can also improve the drug-induced renal damage. The mechanism of anti-apoptosis and anti-fibrosis in recent years is reviewed in order to provide reference for further development and utilization.
【作者单位】： 青海大学附属医院临床药学科;青海省人民医院普外科;
【分类号】：R692
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本文编号：1674411