缬沙坦联合氢氯噻嗪治疗慢性肾脏病合并肾性高血压的临床观察

发布时间：2018-03-29 11:44

本文选题：缬沙坦　切入点：氢氯噻嗪　出处：《中国药房》2017年33期

【摘要】：目的:观察缬沙坦联合氢氯噻嗪治疗慢性肾脏病合并肾性高血压的临床疗效和安全性。方法:156例慢性肾脏病合并肾性高血压患者随机分为对照组和观察组,每组78例。对照组患者给予氢氯噻嗪片25 mg,口服,每日1次,观察组患者在对照组治疗基础上加服缬沙坦胶囊80 mg,每日1次。两组疗程均为4周。观察并比较两组患者临床疗效,治疗前后收缩压(SBP)、舒张压(DBP)、肾小球滤过率(GFR)、24 h尿蛋白定量、血肌肝(Scr)、血尿素氮(BUN)水平及不良反应发生情况。结果:观察组患者临床总有效率显著高于对照组,差异有统计学意义(85.90%vs.64.10%,P0.05)。治疗前,两组患者SBP、DBP、GFR、24 h尿蛋白定量、Scr及BUN比较,差异均无统计学意义(P0.05)。治疗后,两组患者SBP、DBP、24 h尿蛋白定量、Scr及BUN水平显著低于同组治疗前,且观察组显著低于对照组,GFR显著高于同组治疗前,且观察组显著高于对照组,差异均有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:缬沙坦联合氢氯噻嗪治疗慢性肾脏病合并肾性高血压疗效较好,可以显著改善患者血压和肾功能,安全性亦较好。
[Abstract]:Objective: to observe the efficacy and safety of valsartan combined with hydrochlorothiazide in the treatment of chronic kidney disease with renal hypertension. 78 patients in each group were given hydrochlorothiazide tablets 25 mg orally once a day. The patients in the observation group were treated with valsartan capsule 80 mg once a day for 4 weeks. The clinical efficacy of the two groups was observed and compared. The systolic blood pressure (SBP), diastolic blood pressure (DBP), glomerular filtration rate (GFR) and urinary protein were measured before and after treatment. Results: the total effective rate of the patients in the observation group was significantly higher than that in the control group, and the difference was statistically significant (85.90 vs 64.10v. 05). Before treatment, the 24 h urinary protein levels of the two groups were compared with those of the control group. There was no significant difference between the two groups (P 0.05). After treatment, the levels of 24 h urinary protein quantitative creatinine (SCR) and BUN in the two groups were significantly lower than those before the treatment in the same group, and the levels in the observation group were significantly lower than those in the control group before treatment and significantly higher in the observation group than in the control group. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion: valsartan combined with hydrochlorothiazide is effective in the treatment of chronic kidney disease with renal hypertension. It can significantly improve blood pressure and renal function, and the safety is also good.
【作者单位】：胜利油田中心医院肾内科;
【分类号】：R544.14;R692

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