局部补体产生在肾脏损伤中的意义

发布时间：2018-03-31 08:57

本文选题：补体蛋白　切入点：肾脏疾病　出处：《肾脏病与透析肾移植杂志》2015年05期

【摘要】：补体是一组具有酶促反应活性的血清糖蛋白。补体系统参与了多种肾脏损伤的发生与发展,以往认为导致肾脏损伤的补体成分由"肾外"细胞产生(如肝细胞等),通过循环到达肾脏而引起一系列补体介导的免疫反应及免疫损伤。近年国内外研究报道均显示,肝外组织如肾、脑、血管、肺等均能合成补体。肾脏是肝外补体合成的重要场所之一,并且肾脏局部产生的补体可能参与肾脏损伤的发生与发展。本文重点阐述肾脏局部固有细胞产生的补体成分在肾脏损伤中的意义。
[Abstract]:Complement is a group of serum glycoproteins with enzymatic activity.The complement system is involved in the development and development of multiple kidney injuries.In the past, it was believed that the complement components leading to renal injury were produced by "extrarenal" cells (such as hepatocytes, etc.), which caused a series of complement mediated immune responses and immune damage by circulating to the kidneys.In recent years, studies at home and abroad have shown that extrahepatic tissues such as kidney, brain, blood vessels, lung and so on can synthesize complement.The kidney is one of the important sites for the synthesis of extrahepatic complement, and the locally produced complement may be involved in the development of renal injury.This paper focuses on the significance of complement components produced by local intrinsic cells of kidney in renal injury.
【作者单位】：北京大学第一医院儿科;北京大学第一医院肾内科;
【基金】：国家自然科学基金面上项目(81170657);国家自然科学基金重点项目(30830105) 国家重点基础研究发展计划(973,2012CB517700) 北京市自然科学基金(7072080)
【分类号】：R692

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