前列欣联合盐酸坦索罗辛和非那雄胺治疗老年良性前列腺增生的疗效观察

发布时间：2018-03-31 18:51

本文选题：良性前列腺增生　切入点：前列欣胶囊　出处：《中国药房》2017年08期

【摘要】：目的:观察前列欣联合盐酸坦索罗辛和非那雄胺治疗老年良性前列腺增生的临床疗效。方法:选择2012年5月-2014年10月我院确诊为良性前列腺增生的老年患者94例,根据入院单双号分为观察组(48例)和对照组(46例)。两组患者均给予非那雄胺片5 mg,po,qd,对照组患者在此基础上加用盐酸坦索罗辛缓释胶囊0.2 mg,po,qd;观察组患者在对照组基础上加用前列欣胶囊2.5 g,po,tid。两组患者均连续治疗3个月。观察两组患者临床疗效及治疗前后国际前列腺症状量表(IPSS)评分、泌尿症状困扰评分(BS)、勃起功能国际问卷(IIEF-5)评分、超声测量指标和中医证候评分。结果:观察组患者临床总有效率为93.75%,显著高于对照组的76.09%,差异有统计学意义(P0.05)。治疗前,两组患者IPSS、BS、IIEF-5评分及超声测量指标、中医证候评分比较,差异均无统计学意义(P0.05);治疗后,两组患者IPSS、BS、前列腺体积(PV)、残余尿量(RU)、中医证候各项评分及总分均显著降低,IIEF-5评分、最大尿流率(Qmax)显著升高,且观察组明显优于对照组,差异均有统计学意义(P0.05)。结论:前列欣联合盐酸坦索罗辛和非那雄胺治疗老年良性前列腺增生疗效显著,有助于改善良性前列腺增生老年患者的前列腺症状和中医证候,减小PV和RU,改善性功能。
[Abstract]:Objective: to observe the clinical efficacy of Qianliexin combined with tamsoloxine hydrochloride and finasteride in the treatment of benign prostatic hyperplasia in the elderly. Methods: 94 elderly patients with benign prostatic hyperplasia diagnosed in our hospital from May 2012 to October 2014 were selected. The patients in both groups were treated with fenasteride tablets (5 mg / kg) and control group (n = 46). The patients in the control group were treated with tansoloxine hydrochloride sustained release capsule (0.2 mg / kg) and the patients in the control group were treated with fenasteride tablets (0.2 mg / kg poqd), and the patients in the control group were treated with fenasteride tablets (0.2 mg / kg poqd). Two groups of patients were treated continuously for 3 months. The clinical efficacy of the two groups and the IPSS scores before and after treatment were observed. Results: the total effective rate of the patients in the observation group was 93.75, which was significantly higher than that in the control group (76.09), and the difference was statistically significant before treatment (P 0.05). There was no significant difference between the two groups in the scores of IPSS BSU IIEF-5, ultrasound and TCM syndromes (P 0.05). After treatment, the scores of IPSS BSs, prostate volume, residual urine volume and residual urine volume were significantly decreased in both groups, and the scores and total scores of TCM syndromes were significantly decreased. The maximum urinary flow rate (Qmax) was significantly increased, and the observation group was significantly better than the control group (P 0.05). Conclusion: Qianliexin combined with tamsoloxine hydrochloride and finasteride are effective in the treatment of benign prostatic hyperplasia in the elderly. It can improve prostate symptoms and TCM syndromes, reduce PV and RUU, and improve sexual function in elderly patients with benign prostatic hyperplasia.
【作者单位】：河北大学附属医院中西医结合科;河北大学附属医院泌尿外科;河北大学附属医院放疗科;河北大学附属医院康复医学科;
【分类号】：R697+.3

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