慢性肾脏病5期患者高血压的危险因素分析

发布时间：2018-04-04 07:10

本文选题：高血压　切入点：慢性肾脏病期　出处：《华中科技大学学报(医学版)》2015年06期

【摘要】：目的分析慢性肾脏病(CKD)5期患者的高血压相关危险因素。方法收集390例合并有高血压病的CKD5期患者的基本资料,根据性别、年龄、原发病、透析方式、体质量指数(BMI)、合并症(高血脂、高尿酸、心功能不全)、文化程度、血甲状旁腺激素(PTH)水平进行单因素分析;将单因素分析得出的有统计学意义的变量纳入Logistic多因素回归分析,筛选出CKD 5期患者高血压控制的危险因素;并分析高血压分段评估的降压药物限定每日剂量(DDD)。结果该研究高血压总体达标率为22.8%。单因素分析结果显示:年龄40岁、男性、糖尿病肾病、高血压肾病、血液透析、高脂血症、高尿酸、高PTH均具有统计学意义(P0.05,P0.01);Logistic多因素回归分析显示,糖尿病肾病、高脂血症、高PTH是CKD 5期患者高血压的独立危险因素。在高血压的分段评估中,1段和0段的DDD差异无统计学意义(P0.05),2段、3段的DDD较0段和1段明显升高(P0.05)。结论 CKD 5期患者高血压的整体达标率较低;糖尿病、高脂血症、PTH是CKD 5期患者高血压的独立危险因素。
[Abstract]:Objective to analyze the risk factors of hypertension in patients with chronic kidney disease (CKD) stage 5.Methods the basic data of 390 CKD5 patients with hypertension were collected according to sex, age, primary disease, dialysis mode, body mass index (BMI), complications (hyperlipidemia, hyperuric acid, cardiac insufficiency, education level).The serum parathyroid hormone (PTH) level was analyzed by univariate analysis, and the statistical variables obtained by univariate analysis were incorporated into Logistic multivariate regression analysis to screen out the risk factors for hypertension control in patients with stage 5 of CKD.The daily dose limit of antihypertensive drugs was analyzed.Results the overall compliance rate of hypertension in this study was 22. 8%.Univariate analysis showed that age of 40 years, male, diabetic nephropathy, hypertension nephropathy, hemodialysis, hyperlipidemia, hyperuric acid, high PTH were all statistically significant. Logistic multivariate regression analysis showed that diabetic nephropathy, hyperlipidemia, diabetes nephropathy, hyperlipidemia.High PTH is an independent risk factor for hypertension in patients with stage 5 CKD.There was no significant difference in DDD between stage 1 and segment 0 in the segmental assessment of hypertension. The DDD in the third segment of P0.05 was significantly higher than that in stage 0 and stage 1.Conclusion the overall achievement rate of hypertension in patients with CKD 5 is low, and diabetes mellitus and hyperlipidemia are independent risk factors of hypertension in stage 5 of CKD.
【作者单位】：南昌大学第一附属医院肾内科;
【分类号】：R692;R544.1

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