苦碟子注射液静滴辅助替米沙坦口服治疗早期糖尿病肾病效果观察

发布时间：2018-04-08 22:39

本文选题：苦碟子　切入点：替米沙坦　出处：《山东医药》2017年47期

【摘要】：目的观察苦碟子注射液静滴辅助替米沙坦口服治疗早期糖尿病肾病的疗效。方法将148例早期糖尿病肾病患者随机分为观察组和对照组各74例。两组均接受糖尿病的常规治疗并口服替米沙坦;观察组加用苦碟子注射液30 m L,加入250 m L生理盐水静滴,1次/d。观察两组临床疗效,检测两组患者治疗前后血肌酐、24 h尿微量白蛋白泛素-核糖体融合蛋白52(Ub A52)、a-Klotho蛋白。结果观察组显效59例、有效14例、无效1例,总有效率98.6%。对照组分别为40、25、9例,总有效率87.8%。观察组总有效率高于对照组(P0.05)。两组患者治疗后血清肌酐和24 h尿微量白蛋白均较治疗前下降(P均0.05)。观察组患者治疗后血清肌酐和24h尿微量白蛋白均低于对照组治疗后(P均0.05)。与治疗前相比,两组患者治疗后血清Ub A52水平下降,a-Klotho蛋白水平升高(P均0.05)。与对照组治疗后相比,观察组患者治疗后血清Ub A52水平更低,a-Klotho蛋白水平更高(P0.05)。结论苦碟子注射液静滴辅助替米沙坦治疗早期糖尿病肾病效果好于单用替米沙坦。
[Abstract]:Objective to observe the efficacy of kudaizi injection in the treatment of early diabetic nephropathy with oral administration of telmisartan.Methods 148 patients with early diabetic nephropathy were randomly divided into observation group (n = 74) and control group (n = 74).Both groups received routine treatment of diabetes and oral telmisartan, and in the observation group, 30 mL Kudaizi injection was added with 250 mL normal saline intravenously once a day.The clinical efficacy of the two groups was observed and the 24 h urinary albumin ubiquitin ribosomal fusion protein (52(Ub A52) -Klotho protein was detected before and after treatment.Results in the observation group, 59 cases were effective, 14 cases were effective, 1 case was ineffective, and the total effective rate was 98.66%.The total effective rate was 87.8% in the control group.The total effective rate in the observation group was higher than that in the control group (P 0.05).The levels of serum creatinine and 24 h urinary microalbumin in both groups were lower than those before treatment (P < 0.05).The levels of serum creatinine and 24 h urinary microalbumin in the observation group were lower than those in the control group (P < 0.05).Compared with before treatment, the level of serum UbA52 decreased and the level of a-Klotho protein increased after treatment in both groups (P < 0.05).Compared with the control group, the serum UbA52 level in the observation group was lower than that in the control group, and the protein level of a-Klotho was higher than that of the control group (P 0.05).Conclusion Kudaizi injection is more effective than telmisartan alone in the treatment of early diabetic nephropathy.
【作者单位】：广东省第二人民医院;
【分类号】：R587.2;R692.9

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