系膜区IgG沉积对IgA肾病临床及病理影响

发布时间：2018-04-10 17:48

  本文选题：IgA肾病 + 系膜区IgG沉积　； 参考：《南方医科大学学报》2017年03期

【摘要】：目的探讨IgA肾病患者伴系膜区IgG沉积与单纯IgA沉积间临床及病理之间的关系。方法收集自2009年11月~2016年2月于南方医科大学第三附属医院肾活检诊断为IgA肾病患者122例。所有肾活检样本均行光镜、免疫荧光和电镜检查。根据患者免疫荧光结果系膜区有无IgG沉积,将IgA肾病患者分为单纯IgA沉积组(n=63)与IgA-IgG沉积组(n=59)。对所有患者进行Lee分级及牛津分级。对比两组临床及病理差异。结果 IgA肾病伴IgG沉积组临床血肌酐、24小时尿蛋白、血尿酸、甘油三酯水平均高于单纯IgA沉积组(P0.05);eGFR低于单纯IgA沉积组(P0.001);病理中有更多的患者处于Lee氏分级IV-V级、肾小管萎缩或/和间质纤维化评分及MEST评分≥3比例多(P0.05)。结论 IgA肾病系膜区伴IgG沉积患者临床及病理较重,应加强对IgA肾病系膜区伴IgG沉积的认识,延缓IgA肾病的进展。
[Abstract]:Objective to investigate the relationship between IgG deposition in Mesangial region and IgA deposition in patients with IgA nephropathy.Methods from November 2009 to February 2016, 122 patients with IgA nephropathy were diagnosed by renal biopsy in the third affiliated Hospital of Southern Medical University.All renal biopsy samples were examined by light microscopy, immunofluorescence and electron microscopy.According to the results of immunofluorescence, the patients with IgA nephropathy were divided into IgA deposition group (n = 63) and IgA-IgG deposition group (n = 59).All patients were graded with Lee and Oxford.The clinical and pathological differences were compared between the two groups.Results the levels of 24 hour urinary protein, serum uric acid and triglyceride in IgA nephropathy with IgG deposition group were significantly higher than those in IgA deposition group (P 0. 05%, P 0. 001), and there were more patients in Lee grade IV-V grade in pathology.The ratio of tubular atrophy or / and interstitial fibrosis score and MEST score 鈮，

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