前列康片联合盐酸坦索罗辛对老年慢性前列腺炎患者前列腺液中炎性因子及免疫功能的影响

发布时间：2018-04-20 19:56

本文选题：前列康片 + 盐酸坦索罗辛胶囊　；参考：《中国老年学杂志》2017年21期

【摘要】：目的探讨前列康片与盐酸坦索罗辛联合使用治疗老年慢性前列腺炎患者的疗效及其对患者前列腺液中炎性因子及免疫功能的影响。方法将老年慢性前列腺炎患者116例按随机数字表法分为对照组和观察组各58例。其中对照组口服盐酸坦索罗辛胶囊,观察组接受前列康片联合盐酸坦索罗辛胶囊治疗,两组均治疗3个月,对比治疗前后患者前列腺炎症评分(NIH-CP SI)和总有效率,采用酶联免疫吸附法(ELISA)测定治疗前后患者前列腺液中白细胞介素(IL)-2、IL-6、IL-8、肿瘤坏死因子(TNF)-α水平,并对比两组治疗前后免疫细胞亚群的含量及不良反应发生率。结果观察组总有效率显著高于对照组(P0.05)。治疗3个月后观察组NIH-CPSI总评分显著低于对照组(P0.05)。治疗前两组免疫细胞亚群的含量无明显差异(P0.05),治疗3个月后两组CD4~+/CD8~+比值均有回升,且观察组显著高于对照组(均P0.05)。治疗3个月后两组炎症因子水平均显著降低,且观察组低于对照组(均P0.05)。两组总不良反应发生率比较无统计学差异(P0.05)。结论采用前列康片联合盐酸坦索罗辛胶囊治疗老年慢性前列腺炎患者安全有效,并且可提高老年患者的免疫功能,降低前列腺液中炎症因子的水平。
[Abstract]:Objective to investigate the effect of prostacon and tanzosoria hydrochloride in the treatment of senile chronic prostatitis and its effect on inflammatory factors and immune function in the prostatic fluid of the patients. Methods 116 elderly patients with chronic prostatitis were divided into control group and 58 cases in observation group according to random digital table method. Tansorosine capsule and the observation group were treated with proactive tablets combined with tanzosorine hydrochloride capsule. The two groups were treated for 3 months. The scores of prostatitis (NIH-CP SI) and total effective rate were compared before and after the treatment. The ELISA (enzyme linked immunosorbent assay) was used to determine the -2, IL-6, IL-8, and the cause of the tumor's bad death in the anterior gland fluid before and after treatment. The level of subgroup (TNF) - alpha and the incidence of adverse reactions in the immune cells before and after treatment in the two groups were compared. The total effective rate of the observation group was significantly higher than that of the control group (P0.05). The total NIH-CPSI score of the observation group was significantly lower than that of the control group (P0.05) after 3 months of treatment. There was no significant difference between the two groups of immune cell subgroups (P0.05) before treatment (P0.05), and 3 treatment groups. After month, the ratio of the two groups of CD4~+/CD8~+ increased, and the observation group was significantly higher than the control group (P0.05). After 3 months of treatment, the levels of inflammatory factors in the two groups were significantly lower, and the observation group was lower than the control group (P0.05). The incidence of total adverse reactions in the two groups was not statistically different (P0.05). Treatment of elderly patients with chronic prostatitis is safe and effective, and can improve the immune function of elderly patients, and reduce the level of inflammatory factors in prostatic fluid.

【作者单位】：中南大学湘雅三医院泌尿外科;长沙市第三医院泌尿外科;
【分类号】：R697.33

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