慢性肾脏病患者血浆成纤维细胞生长因子23与心血管疾病的关系

发布时间：2018-04-21 09:47

本文选题：慢性肾脏病 + 心血管疾病　；参考：《肾脏病与透析肾移植杂志》2015年04期

【摘要】：慢性肾脏病(CKD)患者心血管并发症发生率较普通人群增高,心血管疾病(CVD)是CKD进展的重要危险因子。CKD患者的矿物质与骨代谢异常(MBD)包括血清全段甲状旁腺激素(i PTH)升高、维生素D缺乏及高磷血症等,均为CVD的独立影响因素。成纤维细胞生长因子23(FGF23)能调节体内磷和维生素D代谢水平。血浆FGF23水平在CKD患者早期即进行性升高,一方面是机体对尿毒症状态的适应性变化,另一方面也是骨病与心血管并发症等病理过程的起始因素。血浆FGF23水平与CKD患者的左心室肥厚(LVH)、血管钙化、心血管功能异常及死亡率增加相关。现将FGF23的生理特点及其与CVD的关系、介导CVD的机制等作一综述。
[Abstract]:The incidence of cardiovascular complications in patients with chronic kidney disease (CKD) is higher than that in the general population. Cardiovascular disease (CVD) is an important risk factor for the progression of CKD. The mineral and bone metabolism abnormalities in patients with CKD include the elevation of serum total parathyroid hormone (PTH). Vitamin D deficiency and hyperphosphatemia were independent factors of CVD. Fibroblast growth factor 23 (FGF23) regulates the metabolism of phosphorus and vitamin D in vivo. Plasma FGF23 level increases progressively in the early stage of CKD patients. On the one hand, it is the adaptive change of body to uremia state, on the other hand, it is the initial factor of pathological process such as bone disease and cardiovascular complications. Plasma FGF23 levels were correlated with left ventricular hypertrophy, vascular calcification, cardiovascular dysfunction and increased mortality in patients with CKD. In this paper, the physiological characteristics of FGF23 and its relationship with CVD and the mechanism of mediating CVD are reviewed.
【作者单位】：南京医科大学第一附属医院肾内科;
【基金】：国家自然科学基金(12981270408) 中华医学会临床科研专项基金首届肾脏病青年研究基金(13030300415) 江苏省“医学重点人才”项目(RC201162) 江苏省“六大人才高峰”资助课题[2010(IB10)]
【分类号】：R692;R54

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