血清NGAL、TRF、hs-CRP及SF在糖尿病肾病诊断中的价值

发布时间：2018-04-23 23:22

本文选题：中性粒细胞明胶酶相关脂质运载蛋白 + 转铁蛋白　；参考：《山东医药》2017年46期

【摘要】：目的探讨血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、转铁蛋白(TRF)、超敏C-反应蛋白(hsCRP)及铁蛋白(SF)检测在糖尿病肾病(DN)诊断中的价值。方法选择2型糖尿病患者284例,依据尿微量白蛋白排泄率(UACR)分为单纯糖尿病组(DM组)、早期糖尿病肾病组(EDN组)、临床糖尿病肾病组(CN组),同时选取健康体检者120例作为对照组(NC组)。采用免疫比浊法检测各组血清NGAL、TRF、hs-CRP水平,用电化学发光法检测SF。用受试者工作特征曲线(ROC)分析各指标的诊断效能。结果 DM组、EDN组和CN组血清NGAL、hs-CRP及SF水平均高于NC组(P均0.01),TRF水平均低于NC组(P均0.01)。EDN组与DM组比较,NGAL、hs-CRP及SF水平均升高,TRF水平降低(P0.05或0.01)。CN组与DM组比较,NGAL、hs-CRP及SF水平均升高,TRF水平降低(P均0.01)。CN组与EDN组比较,NGAL与hs-CRP水平升高(P均0.01)。血清NGAL、TRF、hs-CRP、SF在ROC的曲线下面积分别为0.804、0.789、0.737、0.677,NGAL的特异性最高(92%),hsCRP(82.9%)和SF(81.8%)的敏感性较高。结论血清NGAL、TRF、hs-CRP及SF可作为DN病情进展过程中的监测指标,NGAL和hs-CRP在鉴别早期DN和临床DN中具有一定的价值,NGAL对糖尿病肾损害的特异性高。
[Abstract]:Objective to investigate the diagnostic value of serum neutrophil gelatinase-associated lipid carrier protein (NGALN), transferrin (TRF), hypersensitive C-reactive protein (hsCRP) and ferritin (SF) in the diagnosis of diabetic nephropathy (DN). Methods 284 patients with type 2 diabetes mellitus were selected. According to urinary albumin excretion rate, UACRs were divided into diabetic group, early diabetic nephropathy group and clinical diabetic nephropathy group. At the same time, 120 healthy persons were selected as control group. The levels of TRFhs-CRP in serum of NGALL were detected by immunoturbidimetry, and SFs were detected by electrochemiluminescence (ECL). The diagnostic effectiveness of each index was analyzed by using the operating characteristic curve of subjects. Results the levels of serum NGALHs-CRP and SF in DM group and CN group were higher than those in NC group (P < 0.01). TRF levels were lower in 0.01).EDN group than those in NC group and DM group. The levels of 0.01).EDN and SF were higher than those in DM group (P0.05) or the level of NGALhs-CRP and SF in 0.01).CN group was higher than that in DM group. Compared with EDN group, the levels of NGAL and hs-CRP increased in both 0.01).CN group and EDN group (P < 0.01). The sensitivity of serum NGAL TRFHs-CRPSF under the curve area of 0.804 ~ 0.789 ~ 0.737 ~ (0.677) ~ 0.777 ~ 0.677 ~ (?) was higher than that of ~ (2) ~ (~ (2) ~ (?) ~ (?)) and SF ~ ((81.8)). Conclusion Serum NGALL TRFhs-CRP and SF can be used as markers for monitoring the progression of DN. NGAL and hs-CRP are valuable in differentiating early DN from clinical DN.
【作者单位】：开滦总医院;
【分类号】：R587.2;R692.9

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