幽门螺杆菌感染对膜性肾病患者的血肌酐和血白蛋白及24小时尿蛋白水平的影响研究

发布时间：2018-04-24 17:17

本文选题：幽门螺杆菌感染 + 膜性肾病　；参考：《中华医院感染学杂志》2017年05期

【摘要】：目的探讨幽门螺杆菌感染对膜性肾病患者相关临床指标的实际影响,进而为膜性肾病的相关临床研究提供新思路和指导方向。方法选取医院2014年12月-2015年7月临床收治122例膜性肾病患者为研究对象,根据患者是否感染幽门螺杆菌分为感染组和非感染组,每组61例;针对两组患者血肌酐、血白蛋白和24小时尿蛋白水平以及相关临床炎症因子水平进行观察和比较。结果感染组患者的血肌酐水平为(85.33±11.23)μmol/L,显著高于非感染组(77.38±10.23)μmol/L,且组间比较差异有统计学意义(P0.05);感染组患者血白蛋白和24小时尿蛋白水平分别为(29.34±9.32)g/L和(6.38±1.02)g/24h,与非感染组患者(29.18±9.77)g/L和(6.41±0.98)g/24h之间的差异不大,且无统计学意义;两组患者的CRP、TNF-α和PCT水平差异不大,无统计学意义。结论幽门螺杆菌感染可导致膜性肾病患者血肌酐升高,在一定程度上加重了患者病情,临床针对幽门螺杆菌感染的膜性肾病患者应给予针对性的干预措施。
[Abstract]:Objective to investigate the effect of Helicobacter pylori infection on the clinical indexes in patients with membranous nephropathy, and to provide new ideas and directions for the clinical study of membranous nephropathy. Methods from December 2014 to July 2015, 122 patients with membranous nephropathy were divided into infected group and non-infected group according to whether they were infected with Helicobacter pylori. The levels of serum albumin and 24-hour urinary protein and related clinical inflammatory factors were observed and compared. Results the serum creatinine levels in the infected group were 85.33 卤11.23 渭 mol / L, significantly higher than those in the non-infected group (77.38 卤10.23) 渭 mol / L, and the differences between the two groups were statistically significant (P 0.05), and the serum albumin and 24 hour urinary protein levels in the infected group were 29.34 卤9.32)g/L and 6.38 卤1.02g / 24 h, respectively, and 29.18 卤9.77)g/L in the non-infected group. And 6.41 卤0.98)g/24h. There was no significant difference between the two groups in CRP- TNF- 伪 and PCT levels, but there was no significant difference between the two groups. Conclusion Helicobacter pylori infection can lead to the increase of serum creatinine in patients with membranous nephropathy, and to some extent aggravate the condition of patients. The clinical intervention measures should be given to the patients with membranous nephropathy infected by Helicobacter pylori.
【作者单位】：新乡医学院第一附属医院肾病风湿科;新乡医学院第三附属医院院办;
【基金】：河南省科技厅重点科技攻关基金资助项目(2014326785)
【分类号】：R692

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