不同剂量前列腺素E治疗脓毒症致急性肾损伤的疗效比较

发布时间：2018-04-24 18:28

本文选题：前列腺素E + 脓毒症　；参考：《中国老年学杂志》2017年24期

【摘要】：目的探讨不同剂量前列腺素E治疗脓毒症致急性肾损伤患者的疗效及安全性。方法对86例脓毒症致急性肾损伤患者以数字法随机分成观察组(43例)和对照组(43例)。对照组给予低剂量前列腺素E,观察组给予高剂量前列腺素E,分析不同剂量对患者疗效、炎症因子、肾功能的影响。结果观察组治疗后总有效率为83.72%(36/43)显著高于对照组[62.79%(27/43),P0.05]。治疗前两组白细胞介素(IL)-10及IL-6和肿瘤坏死因子(TNF)-α差异均不显著(P0.05),治疗后观察组IL-10及IL-6和TNF-α水平均显著低于对照组(均P0.05);治疗前两组尿素氮(BUN)、血肌酐(SCr)水平差异均不显著,治疗后3 d及7 d观察组BUN、SCr水平均显著低于对照组(均P0.05);治疗前两组尿N-乙酰-β-D-葡萄糖苷酶(NAG),γ-谷氨酰转肽酶(γ-GTP),α1-微球蛋白(MG)无显著差异(P0.05),治疗后观察组尿NAG、γ-GTP、α1-MG均显著低于对照组(均P0.05)。结论相较于低剂量静脉滴注前列腺素E,高剂量疗效更加显著,还能显著降低体内炎症因子,改善患者肾功能。
[Abstract]:Objective to evaluate the efficacy and safety of prostaglandin E (PGE) in the treatment of acute renal injury caused by sepsis. Methods 86 patients with acute renal injury caused by sepsis were randomly divided into observation group (n = 43) and control group (n = 43). The control group was given low dose prostaglandin E, the observation group was given high dose prostaglandin E, and the effects of different doses on the curative effect, inflammatory factor and renal function were analyzed. Results the total effective rate of the observation group after treatment was 83.72% 36 / 43), which was significantly higher than that of the control group [62.79% 27 / 43 P 0.05]. Before treatment, there was no significant difference in IL-10, IL-6 and TNF- 伪 between the two groups. The levels of IL-10, IL-6 and TNF- 伪 in the observation group were significantly lower than those in the control group after treatment (all P 0.05), and the levels of bun bun and creatinine in the two groups were not significantly different before treatment. 3 and 7 days after treatment, the level of bun SCr in the observation group was significantly lower than that in the control group (all P 0.05), and there was no significant difference between the two groups in urine naga, 纬 -glutamyl transpeptidase (纬 -GTPN) and 纬 -glutamyl transpeptidase (伪 1-microglobulin) before and after treatment (P0.05). After treatment, the urine NAGG, 纬 -TP-GG and 伪 1-MG in the observation group were significantly lower than those in the control group (P < 0.05). It was lower than the control group (P 0.05). Conclusion compared with low dose intravenous infusion of prostaglandin E, high dose prostaglandin E can significantly reduce inflammatory factors and improve renal function.
【作者单位】：胜利油田中心医院重症医学科;
【分类号】：R459.7;R692.5

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