中国中老年社区人群肥胖与慢性肾脏疾病的相关性研究

发布时间：2018-04-24 20:12

  本文选题：慢性肾脏疾病 + 肥胖　； 参考：《上海交通大学学报(医学版)》2017年09期

【摘要】：目的·研究中国中老年社区人群肥胖与慢性肾脏疾病(CKD)的相关性。方法·采取整群抽样的方法对上海市嘉定区10 375名40岁及以上的常住居民进行调查。每位受试者均接受标准化问卷调查、体格检查,同时采集空腹血和晨尿标本检测血糖、血脂、肝功能、肾功能、尿白蛋白、尿肌酐等生化指标。肥胖程度的判断采用世界卫生组织(WHO)的诊断标准,将男性和女性按照体质量指数(BMI)分为正常体质量组(BMI25 kg/m~2)、超重组(25 kg/m2≤BMI30 kg/m2)、肥胖组(BMI≥30 kg/m2)。依据美国CKD流行病学合作研究组(CKD-EPI)方程计算获得估算的肾小球滤过率。采用Logistic回归分析不同BMI水平人群CKD的患病风险。结果·研究对象各项代谢指标均随着BMI水平的升高而趋向恶化。在校正多种因素后,BMI每增加1 kg/m2,CKD患病风险增加9%,其比值比(OR)为1.09(95%CI:1.07~1.12)。多元Logistic回归分析结果显示,超重组和肥胖组的CKD患病风险较正常体质量组分别增加51%(OR=1.51,95%CI:1.27~1.78)和181%(OR=2.81,95%CI:2.20~3.61)。结论·在中国中老年社区人群中,超重和肥胖者CKD患病风险显著升高。
[Abstract]:Objective to study the correlation between obesity and chronic renal disease (CKD) in Chinese middle-aged and elderly community. Methods A cluster sampling method was used to investigate 10 375 residents aged 40 and above in Jiading District, Shanghai. Each of the subjects received standardized questionnaire, physical examination, fasting blood samples and morning urine samples to detect blood glucose, blood lipid, liver function, renal function, urinary albumin, urinary creatinine and other biochemical indicators. According to body mass index (BMI), male and female were divided into two groups: normal body mass group (BMI) 25 kg / m ~ (-2), superrecombinant 25 kg/m2 鈮，

本文编号：1798050