睡眠时间与糖尿病发病率及其肾功能损害的相关性研究

发布时间：2018-04-28 11:07

本文选题：睡眠时间 + 血糖调节受损　；参考：《浙江大学》2017年硕士论文

【摘要】：研究目的及背景睡眠是一种主动的生理活动,合理的睡眠时间让机体得到休息和恢复,而不合理睡眠时间则与许多疾病有着密切的关系,尤其是代谢相关性疾病。本研究主要观察睡眠时间与不同糖代谢状态和糖尿病发病的相关性,以及睡眠时间与糖尿病合并出现肾功能受损的相关性。研究方法采集浙江省杭州市某小区609名研究对象的睡眠时间、糖代谢状况以及肾功能资料。根据WHO糖尿病诊疗标准将研究对象分为正常血糖人群、血糖调节受损人群、糖尿病人群共三组;根据内生肌酐清除率(Ccr)将研究对象分为肾功能正常,肾功能受损两组。采用logistic回归比较分析睡眠时间与研究对象糖代谢的联系,以及睡眠时间与糖尿病合并出现肾功能受损的相关性。研究对象中非糖尿病人群在追踪随访4年后,再次行OGTT检查,根据WHO糖尿病诊疗标准判断该人群中新发糖尿病例数,分析不同睡眠时间对糖尿病发病率的影响。研究结果共有609名研究对象纳入分析,其中血糖调节受损54例,糖尿病92例。睡眠时间过短组(5h/d)的血糖调节受损患病率显著高于睡眠时间正常组(7-9h/d),OR=5.804,95%CI=1.675-20.117,p=0.006,提示睡眠时间过短与血糖调节受损存在相关性。与睡眠时间正常组(7-9h/d)相比较,睡眠时间较短组(5-7h/d)及睡眠时间较长组(9h/d)与血糖调节受损的患病率均不存在显著性差异。对本次研究中非糖尿病患者随访4年后,统计发现睡眠时间过短组(5h/d)出现新发糖尿病的概率显著高于睡眠时间正常组(7-9h/d),睡眠时间过短(5h/d)是糖尿病发病的危险因素。在女性糖尿病患者中,与睡眠时间正常组(7-9h/d)相比,睡眠时间过短/较短组(5h/d或5-7h/d)中糖尿病患者出现肾功能受损比例增大(OR=5.98,95%CI=1.19-30.03,P=0.03)。研究结论睡眠时间过短(5h/d)与出现血糖调节受损存在相关性;睡眠时间过短(5h/d)是糖尿病发病的危险因素,睡眠时间过短/较短组(5h/d或5-7h/d)与女性糖尿病患者合并肾功能损害存在相关性。
[Abstract]:Objective and background Sleep is an active physiological activity. Reasonable sleep time allows the body to rest and recover, while unreasonable sleep time is closely related to many diseases, especially metabolic related diseases. In this study, we observed the correlation between sleep time and different glucose metabolism states and diabetes mellitus, and the correlation between sleep time and renal function impairment. Methods data of sleep time, glucose metabolism and renal function were collected from 609 subjects in Hangzhou, Zhejiang province. According to the criteria of WHO diabetes diagnosis and treatment, the subjects were divided into three groups: normal blood glucose group, impaired blood glucose regulation group and diabetes mellitus group; according to the clearance rate of endogenous creatinine (creatinine clearance rate), the subjects were divided into two groups: normal renal function group and impaired renal function group. The relationship between sleep time and glucose metabolism and the relationship between sleep time and renal function impairment in diabetic patients were analyzed by logistic regression. The non-diabetic subjects were followed up for 4 years, then OGTT was performed again. According to the criteria of WHO diabetes diagnosis and treatment, the number of newly diagnosed diabetes in this population was judged, and the influence of different sleep time on the incidence of diabetes was analyzed. Results A total of 609 subjects were included in the study, including 54 cases of impaired glucose regulation and 92 cases of diabetes mellitus. The prevalence of impaired blood glucose regulation was significantly higher in the short sleep group than that in the normal sleep time group. It was suggested that there was a correlation between the short sleep time and impaired blood glucose regulation, and the incidence of impaired blood glucose regulation was significantly higher than that in the normal sleep time group (5.804 / 95 CI = 1.675-20.117p 0.006). There was no significant difference in the prevalence of impaired blood glucose regulation between the shorter sleep group (5-7 h / d) and the longer sleep time group (9 h / d) compared with the normal sleep time group (7-9 h / d). After a follow-up of 4 years for non-diabetic patients in this study, it was found that the probability of emerging diabetes in the short sleep group was significantly higher than that in the normal sleep time group (7-9 h / d), and the short sleep time (5 h / d) was the risk factor of diabetes. In female diabetic patients, compared with the normal sleep duration group (7-9 h / d), the diabetic patients had increased rate of renal dysfunction in the short / shorter sleep duration group (5h / d or 5-7h / d), and the incidence of renal dysfunction was increased in the diabetic patients (OR5.98 / 95CI1.19-30.03 / d). Conclusion there is a correlation between the short sleep time of 5 h / d and the impaired blood glucose regulation, and the short sleep time of 5 h / d is the risk factor of diabetes. There was a correlation between 5h / d or 5-7h / d sleep duration and renal dysfunction in women with diabetes mellitus.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.2;R692.9

【相似文献】